syn-3 Uses, Dosage, Side Effects, Food Interaction and all others data.

Sodium hyaluronate is a polysaccharide which functions as a tissue lubricant. It is widely used in ophthalmic surgery because it forms a viscoelastic solution in water which makes it a suitable substitute for aqueous and vitreous humour.

Trade Name syn-3
Generic Sodium Hyaluronate
Weight 10mg/ml, 20mg/ml, 8.4mg/ml,
Type Injection, Intra-articular Solution
Therapeutic Class Drugs for Osteoarthritis
Available Country United States
Last Updated: September 19, 2023 at 7:00 am


syn-3 is used for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy, and to simple analgesics, e.g., acetaminophen.

syn-3 is a viscous solution consisting of a high molecular weight fraction of purified natural sodium hyaluronate in buffered physiological sodium phosphate. It has a pH of 5.5-7.0. Hyaluronic acid is an important component of the body's extracellular matrix and is present in a particularly high concentration in cartilage and synovial fluid. Endogenous hyaluronic acid provides viscosity and elasticity to synovial fluid, which is fundamental for its lubricating and shock absorbing properties. It is essential for the correct structure of proteoglycans in articular cartilage. In osteoarthritis there is an insufficient amount of and a chance in the quality of hyaluronic acid in synovial fluid and cartilage. The intra-articular administration of hyaluronic acid into arthritic joints with degenerating cartilage surfaces and pathologically altered synovial fluid improved functions.


syn-3 dosage

syn-3 is administered by intra-articular injection. A treatment cycle consists of five injections given at weekly intervals. Some patients may experience benefit with three injections given at weekly intervals. Inject the full 2 ml in one knee only. If treatment is bilateral, a separate injection should be used for each knee.

Side Effects

The common side-effects include gastrointestinal complaints, injection site pain, knee swelling/effusion, local skin reactions (rash, ecchymosis), pruritus, and headache.


Use caution when injecting syn-3 into patients who are allergic to avian proteins, feathers, and egg products. Strict aseptic administration technique must be followed. Remove joint effusion, if present, before injecting syn-3. Do not use the same syringe for removing joint effusion and for injecting syn-3. It is recommended that the patient avoid any strenuous activities or prolonged (i.e., more than 1 hour) weight-bearing activities such as jogging or tennis within 48 hours following the intra-articular injection.

Pregnancy & Breastfeeding use

The safety and effectiveness of syn-3 have not been established in pregnant women. It is not known if syn-3 is excreted in human milk. The safety and effectiveness of syn-3 have not been established in lactating mother. The safety and effectiveness of syn-3 have not been demonstrated in children.


The drug is contraindicated in patients with known hypersensitivity to hyaluronate preparations. Intra-articular injections are contraindicated in cases of past and present infections or skin diseases in the area of the injection site.

Acute Overdose

No case of over dosage has been reported to date.

Storage Condition

Hyronate injection should be stored in a cool (below 25° C) and dry place and protected from light. Protect from freezing.

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What is syn-3 used for?

syn-3 topical skin medication is used to treat skin ulcers such as bed sores or diabetic foot ulcers, as well as burn wounds, surgical incisions, cuts, abrasions, and other skin irritations. syn-3 skin medication is also used to treat dry or scaly skin.

How safe is syn-3?

syn-3 as well as are considered safe. It's rarely associated with side effects when applied topically.

How does syn-3 work?

syn-3 works by pulling in moisture from the environment and the underlying layers of your skin into the epidermis.

What are the common side effects of syn-3?

The common side effects of syn-3 are include:

  • warmth, pain, redness, stiffness, bruising, or puffiness where the medicine was injected;
  • nausea, stomach pain;
  • trouble walking;
  • swelling in your hands or feet;
  • back pain, joint pain, muscle pain;
  • numbness or tingly feeling;
  • headache, dizziness; or
  • runny or stuffy nose, sneezing, sore throat.

How is syn-3 given?

syn-3 is injected directly into your knee joint. A healthcare provider will give you this injection.
syn-3 is usually given once every week for 3 to 5 weeks. Follow your doctor's dosing instructions very carefully.

Who should not take syn-3?

You should not receive a syn-3 injection if you have an infection in your knee or in the skin around your knee.

Is syn-3 safe during pregnancy?

syn-3 also safe to use during pregnant.

Is syn-3 safe during breastfeeding?

It is not known whether syn-3 topical passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Is syn-3 safe for skin?

syn-3 are considered safe. It's rarely associated with side effects when applied topically.

How long take syn-3?

syn-3 usually given once every week for 3 to 5 weeks.

How long does syn-3 last?

syn-3 lasts for about six months or longer in most people.

How much syn-3 should I take?

Doses of 120–240 mg per day for at least one month have been shown to significantly increase skin moisture and reduce dry skin in adults.

Does syn-3 have long term benefits?

Studies show that long term use is safe, with no reported side effects from syn-3 supplementation. Used as a topical skincare ingredient, syn-3 is also well tolerated.

Is it OK to use syn-3 every day?

Yes, you can even use it twice a day as long as you're applying it to clean, damp skin, then locking it in with a moisturizer and face oil.

What happens if you use too much syn-3?

Too much syn-3 can leave skin thirstier, and dehydration lines more prominent.

Does syn-3 lighten dark spots?

syn-3 can also minimize age spots and prevent any dark spots in the future on your skin.

Can syn-3 dry skin?

syn-3 is one of the most hydrating ingredients, but if misused,syn-3 can actually dry out your skin.

Is syn-3 good for pimples?

While syn-3 can't fill in visible acne scars, it can help reduce redness and the visible appearance of acne.

Is syn-3 good for wrinkles?

syn-3 is well known for its skin benefits, especially alleviating dry skin, reducing the appearance of fine lines and wrinkles and speeding up wound healing.

Is syn-3 good for hair?

You can use syn-3 regardless of your hair type. It'll help your hair follicles lock in moisture.

Can I use syn-3 under eyes?

Yes you can.syn-3 can help mask darkness under the eyes.

What does syn-3 do to your face?

syn-3 helps reduce the visibility of fine lines and wrinkles retaining moisture to the skin.

Can syn-3 cause facial hair growth?

syn-3 is similar to a fertilizer because it can increase hair growth.

What happen If I missed syn-3?

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Use your next dose at the regular time. Do not double the dose to catch up.

What happens if I overdose?

syn-3 may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble a poison control center right away.

*** Taking medicines without doctor's advice can cause long-term problems.