Sustain III

Sustain III Uses, Dosage, Side Effects, Food Interaction and all others data.

A sulfanilamide anti-infective agent. It has a spectrum of antimicrobial action similar to other sulfonamides.

Sustain III is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthetase (dihydrofolate synthetase). Sustain III is bacteriostatic in nature. Inhibition of dihydrofolic acid synthesis decreases the synthesis of bacterial nucleotides and DNA.

Trade Name Sustain III
Generic Sulfamethazine
Sulfamethazine Other Names Sulfadimethyldiazine, Sulfadimethylpyrimidine, Sulfadimidina, Sulfadimidine, Sulfadimidinum, Sulfametazina, Sulfametazyny, Sulfamethazine, Sulfamezathine, Sulphadimethylpyrimidine, Sulphamethazine
Type For animal use only
Formula C12H14N4O2S
Weight Average: 278.33
Monoisotopic: 278.083746402
Groups Approved, Investigational, Vet approved
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Sustain III
Sustain III

Uses

Sustain III is an antibacterial agent used in the treatment of various bacterial infections, such as bronchitis, prostatitis, and urinary tract infections.

For the treatment bacterial infections causing bronchitis, prostatitis and urinary tract infections.

Sustain III is also used to associated treatment for these conditions: Bacterial Conjunctivitis, Endometritis, Furuncle, Streptococcal Sore Throat, Ulcers, Urinary Tract Infection

How Sustain III works

Sulfonamides inhibit the enzymatic conversion of pteridine and p-aminobenzoic acid (PABA) to dihydropteroic acid by competing with PABA for binding to dihydrofolate synthetase, an intermediate of tetrahydrofolic acid (THF) synthesis. THF is required for the synthesis of purines and dTMP and inhibition of its synthesis inhibits bacterial growth. Pyrimethamine and trimethoprim inhibit dihydrofolate reductase, another step in THF synthesis, and therefore act synergistically with the sulfonamides.

Toxicity

Sustain III may cause nausea, vomiting, diarrhea and hypersensitivity reactions. Hematologic effects such as anemia, agranulocytosis, thrombocytopenia and hemolytic anemia in patients with glucose-6-phosphate dehydrogenase deficiency may also occur. Sulfamethoxazole may displace bilirubin from albumin binding sites causing jaundice or kernicterus in newborns.

Food Interaction

No interactions found.

Elimination Route

Rapidly absorbed following oral administration.

Innovators Monograph

You find simplified version here Sustain III

*** Taking medicines without doctor's advice can cause long-term problems.
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