Suramin

Suramin Uses, Dosage, Side Effects, Food Interaction and all others data.

A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties. Suramin is manufactured by Bayer in Germany as Germanin®.

Trade Name Suramin
Generic Suramin
Suramin Other Names Suramin, Suramine
Type
Formula C51H40N6O23S6
Weight Average: 1297.28
Monoisotopic: 1296.046905756
Protein binding

Approximately 99.7%

Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Suramin
Suramin

Uses

For treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms.

How Suramin works

The mechanism is unknown, but the trypanocidal activity may be due to the inhibition of enzymes involved with the oxidation of reduced nicotinamide-adenine dinucleotide (NADH), which functions as a co-enzyme in many cellular reactions, such as respiration and glycolysis, in the trypanosome parasite. Suramin's action in the treatment of onchocerciasis is macrofilaricidal and partially microfilaricidal. It may also act as an antagonist of P2 receptors and as an agonist of Ryanodine receptors. It also can inhibit follicle-stimulating hormone receptors.

Elimination Route

Poorly absorbed from the gastrointestinal tract.

Half Life

Approximately 36 to 60 days

Innovators Monograph

You find simplified version here Suramin

*** Taking medicines without doctor's advice can cause long-term problems.
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