Sulfur Hexafluoride

Sulfur Hexafluoride Uses, Dosage, Side Effects, Food Interaction and all others data.

Sulfur Hexafluoride is an ultrasound contrast agent indicated for useā€¢in echocardiography to opacify the left ventricular chamber and to improve the delineation of the left ventricular endocardial border in adult patients with suboptimal echocardiogramsā€¢in ultrasonography of the liver for characterization of focal liver lesions in adult and pediatric patients

Sulfur Hexafluoride provides useful echocardiographic signal intensity for two minutes after the injection. Sulfur Hexafluoride microspheres are destroyed and contrast enhancement decreases as the mechanical index increases (values of 0.8 or less are recommended).For ultrasonography of the liver, Sulfur Hexafluoride provides dynamic patterns of differential signal intensity enhancement between focal liver lesions and liver parenchyma during the arterial, portal venous, and late phase of signal intensity enhancement of the microvasculature.

Trade Name Sulfur Hexafluoride
Generic Sulfur hexafluoride
Sulfur hexafluoride Other Names hexafluoridosulfur, Sulfur fluoride, Sulfur hexafluoride, sulfur(6+) fluoride, sulfur(VI) fluoride, Sulphur hexafluoride
Weight +
Type Intravenous powder for injection
Formula F6S
Weight Average: 146.05
Monoisotopic: 145.962490152
Groups Approved
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Sulfur Hexafluoride
Sulfur Hexafluoride

Uses

Sulfur Hexafluoride is a medication used in ultrasound to enhance viewing of blood vessels and the urinary tract.

Echocardiography: Sulfur Hexafluoride is indicated for use in adult patients with suboptimal echocardiograms to opacify the left ventricular chamber and to improve the delineation of the left ventricularendocardial border. Ultrasonography of the Liver: Sulfur Hexafluoride is indicated for use with ultrasound of the liver in adult and pediatric patients to characterize focal liver lesions.

How Sulfur Hexafluoride works

Within the blood, the acoustic impedance of Lumason microspheres is lower than that of the surrounding non-aqueous tissue. Therefore, an ultrasound beam is reflected from the interface between the microspheres and the surrounding tissue. The reflected ultrasound signal provides a visual image that shows a contrast between the blood and the surrounding tissues.

Food Interaction

No interactions found.

Volume of Distribution

In a study of healthy subjects, the mean values for the apparent steady-state volume of distribution of SF6 were 341 L and 710 L for Lumason doses of 0.03 mL/kg and 0.3 mL/kg, respectively. Preferential distribution to the lung is likely responsible for these values.

Elimination Route

The pharmacokinetic of the SF6 gas component of Lumason was evaluated in 12 healthy adult subjects (7 men and 5 women). After intravenous bolus injections of 0.03 mL/kg and 0.3 mL/kg of Lumason, corresponding to approximately 1 and 10 times the recommended doses, concentrations of SF6 in blood peaked within 1 to 2 minutes for both doses.

Half Life

The terminal half-life of SF6 in blood was approximately 10 minutes for the 0.3 mL/kg dose. (At the 0.03 mL/kg dose, terminal half-life could not be estimated.)

Elimination Route

The SF6 component of Lumason is eliminated via the lungs.

Innovators Monograph

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