Streptozotocin

Streptozotocin Uses, Dosage, Side Effects, Food Interaction and all others data.

An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.

Streptozotocin is an antitumour antibiotic consisting of a nitrosourea moiety interposed between a methyl group and a glucosamine. Streptozotocin is indicated in the treatment of metastatic islet cell carcinoma of the pancreas. Streptozotocin inhibits DNA synthesis in bacterial and mammalian cells. In bacterial cells, a specific interaction with cytosine moieties leads to degradation of DNA. The biochemical mechanism leading to mammalian cell death has not been definitely established; streptozocin inhibits cell proliferation at a considerably lower level than that needed to inhibit precursor incorporation into DNA or to inhibit several of the enzymes involved in DNA synthesis. Although streptozocin inhibits the progression of cells into mitosis, no specific phase of the cell cycle is particularly sensitive to its lethal effects.

Streptozotocin
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
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Trade Name	Streptozotocin
Availability	Prescription only
Generic	Streptozocin
Streptozocin Other Names	Estreptozocina, Streptozocin, Streptozocine, Streptozocinium, Streptozocinum, Streptozotocin
Related Drugs	fluorouracil, gemcitabine, everolimus, Lynparza, Abraxane, Afinitor
Type
Formula	C₈H₁₅N₃O₇
Weight	Average: 265.2206 Monoisotopic: 265.090999849
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Streptozotocin is a nitrosourea antineoplastic agent used in the treatment of metastatic pancreatic islet cell carcinoma.

For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma).

Streptozotocin is also used to associated treatment for these conditions: Stage 4 islet cell carcinoma

How Streptozotocin works

Although its mechanism of action is not completely clear, streptozocin is known to inhibit DNA synthesis, interfere with biochemical reactions of NAD and NADH, and inhibit some enzymes involved in gluconeogenesis. Its activity appears to occur as a result of formation of methylcarbonium ions, which alkylate or bind with many intracellular molecular structures including nucleic acids. Its cytotoxic action is probably due to cross-linking of strands of DNA, resulting in inhibition of DNA synthesis.