Sodium Hypochlorite

Sodium Hypochlorite Uses, Dosage, Side Effects, Food Interaction and all others data.

Sodium Hypochlorite hydrochloride is an antimuscarinic antiparkinsonian agent of relatively low toxicity. It is a synthetic tertiary amine. This drug exerts their antiparkinsonian effect by correcting the relative cholinergic excess which is thought to occur in parkinsonian as a result of dopamine deficiency. It is absorbed from G.I. tract and disappears rapidly from the tissues. After intravenous administration, it acts within 5 to 20 minutes and has a duration of effect up to 4 hours.

Sodium Hypochlorite has an atropine-like action on parasympathetic-innervated peripheral structures including smooth muscle. It's antispasmodic effects are thought to be related to the blockage of central cholinergic receptors M1, M2 and M4. It is used to treat symptomatic Parkinsonism and extrapyramidal dysfunction caused by antipsychotic agents.

Trade Name Sodium Hypochlorite
Availability Discontinued
Generic Procyclidine
Procyclidine Other Names Prociclidina, Procyclidin, Procyclidine, Procyclidinum, Tricyclamol
Related Drugs Gocovri, diphenhydramine, Benadryl, benztropine, amantadine, Cogentin, Kemadrin
Type Solution
Formula C19H29NO
Weight Average: 287.4397
Monoisotopic: 287.224914555
Protein binding

Approximately 100% bound to albumin.

Groups Approved
Therapeutic Class Antiparkinson drugs
Manufacturer Mumbai Healthcare Industries
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Sodium Hypochlorite
Sodium Hypochlorite

Uses

Sodium Hypochlorite is used for the adjunctive treatment of all forms of parkinsonian syndrome. It is mainly used for the symptomatic treatment of idiopathic (paralysis agitants), postencephalitic and arteriosclerotic parkinsonian. It is used to control troublesome extrapyramidal symptoms including pseudoparkinsonian, acute dystonic reactions and akathisia induced by neuroleptic drugs such as phenothiazine derivatives.

Sodium Hypochlorite is also used to associated treatment for these conditions: Parkinsonian Syndromes, Extrapyramidal reaction

How Sodium Hypochlorite works

The mechanism of action is unknown. It is thought that Sodium Hypochlorite acts by blocking central cholinergic receptors, and thus balancing cholinergic and dopaminergic activity in the basal ganglia. Many of its effects are due to its pharmacologic similarities with atropine. Sodium Hypochlorite exerts an antispasmodic effect on smooth muscle, and may produce mydriasis and reduction in salivation.

Dosage

Sodium Hypochlorite dosage

Oral administration:

Adults: Sodium Hypochlorite tablet is administered orally, preferably after meals.

  • Parkinsonism: Initially 2.5 mg 3 times a day, then 5 mg 3 times a day and occasionally 5 mg at bed time. The dosage being adjusted as tolerated or until the total daily dose reaches 20 to 30 mg divided into 3 to 4 doses.
  • Drug induced extrapyramidal symptom: Initially 2.5 mg 3 times a day. The dosage being increased by 2.5 mg increment per day as needed and tolerated.

Children: Safety and efficacy have not been established in the pediatric age group; therefore, the use of procyclidine hydrochloride in this age group requires that the potential benefits be weighed against the possible hazards to children.

IM or IV administration:

By intramuscular or intravenous injection, 5-10 mg, repeated if necessary after 20 minutes; maximum 20 mg daily can be given.

Side Effects

At usual dosage levels dryness of the mouth is generally the only adverse effect. Mydriasis, blurred vision and adverse G.I. effects (nausea, vomiting, epigastric distress, constipation) occur occasionally. An allergic reaction (e.g. rash) or muscular weakness may occasionally occur. High doses may cause vertigo and possibly confusion and hallucination. Adverse effect may usually be minimized by adjustment of dosage and administration after meal.

Toxicity

LD50=60 mg/kg (IV in mice)

Precaution

Precaution should be taken in case of hepatic & renal impairment, children, elderly, pregnancy and lactation condition. Patients with mental disorders occasionally experience a precipitation of a psychotic episode when Sodium Hypochlorite is administered for the treatment of the extrapyramidal side-effects of neuroleptic. Sodium Hypochlorite should not be withdrawn abruptly as rebound Parkinsonism symptoms may occur.

Interaction

The anticholinergic activity of procyclidine may be increased by agents having anticholinergic amantadine. The absorption of ketoconazole may be reduced by concomitant administration of procyclidine.

Food Interaction

  • Take with or without food. Taking with food may reduce the adverse effects of procyclidine.

Sodium Hypochlorite Alcohol interaction

[Moderate] GENERALLY AVOID:

Use of anticholinergic agents with alcohol may result in sufficient impairment of attention so as to render driving and operating machinery more hazardous.

In addition, the potential for abuse may be increased with the combination.

The mechanism of interaction is not established but may involve additive depressant effects on the central nervous system.

No effect of oral propantheline or atropine on blood alcohol levels was observed in healthy volunteers when administered before ingestion of a standard ethanol load.

However, one study found impairment of attention in subjects given atropine 0.5 mg or glycopyrrolate 1 mg in combination with alcohol.

Alcohol should generally be avoided during therapy with anticholinergic agents.

Patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them.

Sodium Hypochlorite Hypertension interaction

[Minor] Cardiovascular effects of anticholinergics may exacerbate hypertension.

Therapy with anticholinergic agents should be administered cautiously in patients with hypertension.

Pregnancy & Breastfeeding use

The safe use of this drug in pregnancy, lactation or in women of childbearing age requires that the potential benefits be weighed against the possible hazards to the mother and child.

Contraindication

It should be given with caution in children and geriatric patients. It is advisable to be cautious in giving Sodium Hypochlorite to patients with diarrhoea and cardiovascular disease, glaucoma, urinary retention, hepatic or renal impairment. The safety of using procyclidine during pregnancy has not been established. No data are available on the excretion of this drug in breast milk.

Storage Condition

Store between 15-30° C. Protect from moisture.

Innovators Monograph

You find simplified version here Sodium Hypochlorite

Sodium Hypochlorite contains Procyclidine see full prescribing information from innovator Sodium Hypochlorite Monograph, Sodium Hypochlorite MSDS, Sodium Hypochlorite FDA label

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0004707
http://classyfire.wishartlab.com/tax_nodes/C0000278
http://classyfire.wishartlab.com/tax_nodes/C0002449
http://classyfire.wishartlab.com/tax_nodes/C0003899
http://classyfire.wishartlab.com/tax_nodes/C0003449
http://classyfire.wishartlab.com/tax_nodes/C0002279
http://classyfire.wishartlab.com/tax_nodes/C0001670
http://classyfire.wishartlab.com/tax_nodes/C0001852
http://classyfire.wishartlab.com/tax_nodes/C0002239
http://classyfire.wishartlab.com/tax_nodes/C0004139
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0003073
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:8448
http://www.hmdb.ca/metabolites/HMDB0014531
http://www.genome.jp/dbget-bin/www_bget?drug:D08425
http://www.genome.jp/dbget-bin/www_bget?cpd:C07378
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4919
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505553
https://www.chemspider.com/Chemical-Structure.4750.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50062598
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=8718
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=8448
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL86715
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP001110
http://www.pharmgkb.org/drug/PA164784001
https://www.drugs.com/cdi/procyclidine.html
https://en.wikipedia.org/wiki/Procyclidine
*** Taking medicines without doctor's advice can cause long-term problems.
Share