Sodium Hydroxide

Sodium Hydroxide Uses, Dosage, Side Effects, Food Interaction and all others data.

Sodium Hydroxide is also known as lye or soda , or caustic soda .

At room temperature, sodium hydroxide is a white crystalline odorless solid that absorbs moisture from the air. It is a synthetically manufactured substance. When dissolved in water or neutralized with acid it releases substantial amounts of heat, which may prove sufficient to ignite combustible materials. Sodium Hydroxide is highly corrosive .

Sodium Hydroxide is generally used as a solid or a diluted in a 50% solution. This chemical is used to manufacture soaps, rayon, paper, explosives, dyestuffs, and petroleum products .

Sodium Hydroxide
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Sodium Hydroxide
Generic	Sodium hydroxide
Sodium hydroxide Other Names	caustic soda, soda lye, sodio hidróxido, sodium hydrate, Sodium hydroxide, white caustic
Type
Formula	HNaO
Weight	Average: 39.9971 Monoisotopic: 39.992509329
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Used to destroy or kill the nail matrix (matrixectomies) .

Sodium Hydroxide is also used to associated treatment for these conditions: Dehydration Hypertonic, Isotonic Dehydration, Nail Removal, Organ Preservation, Parenteral Nutrition

How Sodium Hydroxide works

Because of its high-level alkalinity, sodium hydroxide in aqueous solution directly causes bond breakage in proteins (especially disulfide bridges). Hair and fingernails are found to be dissolved after 20 hours of direct contact with sodium hydroxide at pH values higher than 9.2 .

Sodium Hydroxide has depilatory effects which have been described after accidental contact with solutions in the workplace. The breakage of bonds in proteins may lead to severe necrosis to the application site. The level of corrosion depends on the period of contact with the tissue, and on the concentration of sodium hydroxide .

Toxicity

Human poisoning cases indicate that a dose of 10 grams orally is fatal . Sodium Hydroxide is toxic by oral ingestion .

Sodium Hydroxide is corrosive to all tissues. Concentrated vapors lead to serious damage to the eyes and respiratory system. Oral ingestion of sodium hydroxide, which occurs frequently in children, causes severe tissue necrosis, with stricture formation of the esophagus, often resulting in death. Contact with the skin may result in contact dermatitis, hair loss, as well as necrosis due to severe irritation .

Increased incidence of esophageal carcinoma after severe intoxication with sodium hydroxide has been reported in man. In animal studies, long-term dermal contact with substances leading to pH changes in the skin causes the development of tumors, as a result of severe tissue irritation and reparative cell growth .

Mutagenic for mammalian somatic cells. May cause damage to the following organs: mucous membranes, upper respiratory tract, skin, eyes . Tumors are not to be expected if the effects of irritation are prevented .

To date, there are no relevant studies of the prenatal toxic effects of sodium hydroxide .

Food Interaction

No interactions found.

Elimination Route

There are no quantitative data for the absorption of sodium hydroxide through the skin. Solutions which contain 50 % sodium hydroxide have been shown to be corrosive and lethal when applied dermally to mice .