Sodium Aurothiomalate

Sodium Aurothiomalate Uses, Dosage, Side Effects, Food Interaction and all others data.

Sodium Aurothiomalate is a gold compound that is used for its immunosuppressive anti-rheumatic effects. Gold Sodium Thiomalate is supplied as a solution for intramuscular injection containing 50 mg of Gold Sodium Thiomalate per mL. It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence of extensive deformities or in the treatment of other forms of arthritis.

Unknown, may decrease prostaglandin synthesis or may alter cellular mechanisms by inhibiting sulfhydryl systems.

Sodium Aurothiomalate
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Sodium Aurothiomalate
Generic	Sodium aurothiomalate
Sodium aurothiomalate Other Names	Aurotiomalato sodico, Gold sodium thiomalate, Natrii aurothiomalas, Sodium aurothiomalate
Type
Formula	C₄H₃AuNa₂O₄S
Weight	Average: 390.07 Monoisotopic: 389.921312
Protein binding	About 85-90% of the drug is protein bound.
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Sodium Aurothiomalate is a disease-modifying antirheumatic drug (DMARD) indicated for the symptomatic treatment of arthritis.

A disease-modifying antirheumatic drug (DMARD) indicated for the symptomatic treatment of arthritis.

Sodium Aurothiomalate is also used to associated treatment for these conditions: Felty's Syndrome, Psoriatic Arthritis, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile

How Sodium Aurothiomalate works

The precise mechanism of action is unknown. It is known that sodium aurothiomalate inhibits the synthesis of prostaglandins. The predominant action appears to be a suppressive effect on the synovitis of active rheumatoid disease.

Toxicity

Overdosage symptoms are those of heavy metal toxicity; they include pruritus, dermatitis, stomatitis, vague gastrointestinal discomfort, albuminuria with or without a nephrotic syndrome, hematuria, agranulocytosis, thrombocytopenic purpura, and aplastic anemia.

Food Interaction

No interactions found.

Volume of Distribution

The apparent volume of distribution is 0.26 +/- 0.051 kg-1

Elimination Route

Gold sodium thiomalate solutions are rapidly absorbed following IM injection, with peak serum concentrations occurring in 3-6 hours.

Half Life

12.5 days

Clearance

7.0 ml/ kg/day

Elimination Route

The major route of elimination of an IV dose of gold sodium thiomalate is urinary excretion, with a mean of 35% of the dose found in the urine in ten days. Fecal elimination accounts for an additional 9.4% of the IV dose excreted in ten days, probably as a result of biliary secretion.