Silibinine
Silibinine Uses, Dosage, Side Effects, Food Interaction and all others data.
Silibinine is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin and others. Silibinine is presented as a mixture of two diastereomers, silybin A and silybin B, which are found in an approximately equimolar ratio. Both in vitro and animal research suggest that silibinin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins. Silibinine has also demonstrated in vitro anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent and -independent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells.
| Trade Name | Silibinine |
| Generic | Silibinin |
| Silibinin Other Names | Silibinin, Silibinin A, Silibinina, Silibinine, Silibininum, Silybin A, Silymarin I |
| Type | |
| Formula | C25H22O10 |
| Weight | Average: 482.441 Monoisotopic: 482.121296908 |
| Groups | Experimental, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Silibinine is a flavonolignan with hepatoprotective effects used to treat toxic liver damage and as an adjunct in the management of chronic conditions such as cirrhosis and hepatitis.
Currently being tested as a treatment of severe intoxications with hepatotoxic substances, such as death cap (Amanita phalloides) poisoning.
Silibinine is also used to associated treatment for these conditions: Acute Hepatitis, Amanita Poisoning, Cirrhosis of the Liver, Clinical Deterioration of the Liver, Fatty Liver Disease, Hepatitis, Chronic, Liver Diseases, Alcoholic, Non-Alcoholic Steatohepatitis, Non-alcoholic Fatty Liver, Recurrent Hepatitis, Uncomplicated hepatic dysfunction
Innovators Monograph
You find simplified version here Silibinine
