Rythmodan
Rythmodan Uses, Dosage, Side Effects, Food Interaction and all others data.
Rythmodan’s Class 1a activity is similar to that of quinidine in that it targets sodium channels to inhibit conduction. Rythmodan depresses the increase in sodium permeability of the cardiac Myocyte during Phase 0 of the cardiac action potential, in turn decreasing the inward sodium current. This results in an increased threshold for excitation and a decreased upstroke velocity.
Rythmodan prolongs the PR interval by lengthening both the QRS and P wave duration. This effect is particularly well suited in the treatment of ventricular tachycardia as it slows the action potential propagation through the atria to the ventricles.
Rythmodan does not act as a blocking agent for beta or alpha adrenergic receptors, but does have a significant negative inotropic effect on the ventricular myocardium. As a result, the use of disopyramide may reduce contractile force up to 42% at low doses and up to 100% in higher doses leading to heart failure.
This provides a possible treatment for atrial and ventricular fibrillation, as it restores pacemaker control of the tissue to the SA and AV nodes.
Rythmodan is an anti-arrhythmic drug indicated for the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia that are life-threatening. At therapeutic plasma levels, disopyramide shortens the sinus node recovery time, lengthens the effective refractory period of the atrium, and has a minimal effect on the effective refractory period of the AV node. Little effect has been shown on AV-nodal and His-Purkinje conduction times or QRS duration. However, prolongation of conduction in accessory pathways occurs.
Trade Name | Rythmodan |
Availability | Prescription only |
Generic | Disopyramide |
Disopyramide Other Names | Disopiramida, Disopyramide, Disopyramidum |
Related Drugs | propranolol, amiodarone, lidocaine, verapamil, Inderal, dofetilide |
Type | |
Formula | C21H29N3O |
Weight | Average: 339.4745 Monoisotopic: 339.231062565 |
Protein binding | 50%-65% |
Groups | Approved |
Therapeutic Class | Membrane stabilizing agent (Sodium channel blockers) |
Manufacturer | |
Available Country | Canada, Australia, United States, |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Rythmodan is used for the ventricular arrhythmias, especially after myocardial infarction, supraventricular arrhythmias.
Rythmodan is also used to associated treatment for these conditions: Arrhythmia of ventricular origin
How Rythmodan works
Rythmodan is a Type 1A antiarrhythmic drug (ie, similar to procainamide and quinidine). It inhibits the fast sodium channels. In animal studies Rythmodan decreases the rate of diastolic depolarization (phase 4) in cells with augmented automaticity, decreases the upstroke velocity (phase 0) and increases the action potential duration of normal cardiac cells, decreases the disparity in refractoriness between infarcted and adjacent normally perfused myocardium, and has no effect on alpha- or beta-adrenergic receptors.
Dosage
Rythmodan dosage
The recommended dose of Rythmodan is 400 mg /day in 4 divided doses (100 mg capsule 6 hourly).
Patients with renal insufficiency should take 100 mg capsule according to the schedule given below:
Creatinine clearance (ml/min) >15: Approximate dosing q 8 hrq 12 hrq 24 hr
Patients in whom rapid control of ventricular arrhythmia is essential, an initial loading dose of 300 mg Rythmodan is recommended, followed by the appropriate maintenance dosage.
Side Effects
Usually Rythmodan is well tolerated but occasionally in some cases dry mouth/ nose/ eye, nausea, vomiting, diarrhea, bloating, blurred vision, urinary problems, headache, skin rash, dizziness, nervousness & impotence (1-3%) may occur.
Toxicity
LD50=580 mg/kg in rats
Precaution
Rythmodan should not be administered to patients with cardiomyopathy and associated congestive heart failure unless the patient is digitalized and adequately compensated. Rythmodan should be used with caution in the presence of digitalis intoxication.
Food Interaction
- Avoid alcohol.
- Take with or without food. The absorption is unaffected by food.
[Moderate] MONITOR: Grapefruit juice may increase the plasma concentrations of orally administered drugs that are substrates of the CYP450 3A4 isoenzyme.
The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit.
Because grapefruit juice inhibits primarily intestinal rather than hepatic CYP450 3A4, the magnitude of interaction is greatest for those drugs that undergo significant presystemic metabolism by CYP450 3A4 (i.e., drugs with low oral bioavailability).
In general, the effect of grapefruit juice is concentration-, dose- and preparation-dependent, and can vary widely among brands.
Certain preparations of grapefruit juice (e.g., high dose, double strength) have sometimes demonstrated potent inhibition of CYP450 3A4, while other preparations (e.g., low dose, single strength) have typically demonstrated moderate inhibition.
Pharmacokinetic interactions involving grapefruit juice are also subject to a high degree of interpatient variability, thus the extent to which a given patient may be affected is difficult to predict.
MANAGEMENT: Patients who regularly consume grapefruit or grapefruit juice should be monitored for adverse effects and altered plasma concentrations of drugs that undergo significant presystemic metabolism by CYP450 3A4.
Grapefruit and grapefruit juice should be avoided if an interaction is suspected.
Orange juice is not expected to interact with these drugs.
Rythmodan Alcohol interaction
[Minor] Ethanol significantly increases the renal elimination of disopyramide, apparently by inducing diuresis (inhibition of antidiuretic hormone).
Limited data show that ethanol does not, however, significantly affect the elimination half-life or total plasma clearance of disopyramide. No special precautions appear to be necessary.
Rythmodan Drug Interaction
Major: metoprolol, metoprololModerate: diphenhydramine, diphenhydramineUnknown: aspirin, aspirin, rosuvastatin, rosuvastatin, duloxetine, duloxetine, apixaban, apixaban, acetaminophen, acetaminophen, clopidogrel, clopidogrel, ascorbic acid, ascorbic acid, cholecalciferol, cholecalciferol
Elimination Route
Nearly complete
Half Life
6.7 hours (range 4-10 hours)
Elimination Route
In healthy men, about 50% of a given dose of disopyramide is excreted in the urine as the unchanged drug, about 20% as the mono-N-dealkylated metabolite and 10% as the other metabolites.
Pregnancy & Breastfeeding use
Pregnancy: There are no adequate and well-controlled studies in pregnant women. Rythmodan should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Lactation: Because of the potential for serious adverse reactions in nursing infants from Rythmodan, a decision should be made whether to discontinue nursing or to discontinue the drug , taking into account the importance of the drug to the mother
Contraindication
Rythmodan is contraindicated in the pre-existing A-V heart block, shock, glaucoma, urinary retention and known hypersensitivity to the drug.
Acute Overdose
Deliberate or accidental over dosage of oral Rythmodan may be followed by apnea, loss of consciousness & loss of spontaneous respiration. In such a case immediate hospitalization and all life saving measures should be taken.
Innovators Monograph
You find simplified version here Rythmodan
Rythmodan contains Disopyramide see full prescribing information from innovator Rythmodan Monograph, Rythmodan MSDS, Rythmodan FDA label