Rupatan

Rupatan Uses, Dosage, Side Effects, Food Interaction and all others data.

Rupatan is a second generation, non-sedating, long-acting histamine antagonist with selective peripheral H1 receptor antagonist activity. It further blocks the receptors of the platelet-activating factor (PAF) according to in vitro and in vivo studies.

Rupatan possesses anti-allergic properties such as the inhibition of the degranulation of mast cells induced by immunological and non-immunological stimuli, and inhibition of the release of cytokines, particularly of the tumor necrosis factors (TNF) in human mast cells and monocytes.

Rupatan is an anti allergenic and acts to reduce allergic symptoms like urticaria, rhinorrhea, sneezing and itching .

Trade Name Rupatan
Generic Rupatadine
Rupatadine Other Names Rupatadina, Rupatadine
Weight 10mg
Type Tablet
Formula C26H26ClN3
Weight Average: 415.97
Monoisotopic: 415.1815255
Protein binding

Rupatidine is 98.5-99.0% bound to human plasma proteins .

Groups Approved
Therapeutic Class Non-sedating antihistamines
Manufacturer Novo Healthcare and Pharma Ltd
Available Country Bangladesh
Last Updated: September 19, 2023 at 7:00 am
Rupatan
Rupatan

Uses

Rupatan is used for the symptomatic treatment of seasonal & perennial allergic rhinitis and urticaria.

Rupatan is also used to associated treatment for these conditions: Allergic Rhinitis (AR), Pruritus, Urticaria

How Rupatan works

Rupatan is a dual histamine H1 receptor and platelet activating (PAF) receptor antagonist . During allergic response mast cells undergo degranulation, releasing histamine and other substances . Histamine acts on H1 receptors to produce symptoms of nasal blockage, rhinorhea, itching, and swelling. PAF is produced from phospholipids cleaved by phospholipase A2. It acts to produce vascular leakage which contributes to rhinorhea and nasal blockage. By blocking both the H1 receptor and PAF receptor, rupatidine prevents these mediators from exerting their effects and so reduces the severity of allergic symptoms.

Dosage

Rupatan dosage

Rupatan Tablet: The recommended dosage is 10 mg once daily, with or without food.

Rupatan Oral Solution (Children aged 2 to 11 year):

  • Children weighing 25 kg or more: 1 teaspoonful (5 ml) of oral solution once daily with or without food.
  • Children weighing equal or more than 10 kg to less than 25 kg: 1/2 teaspoonful (2.5 ml) oral solution once daily with or without food.

Side Effects

The most common undesirable effects occurs somnolence, headache and fatigue. Other common undesirable effects include dizziness, asthenia and increase appetite.

Precaution

Administration of a dose of 10 mg daily of Rupatan has not shown significant effects on the function of the central nervous system as seen in specific studies done for psychomotor function. Nevetheless, the patient should take precaution in driving or managing machines. The administration of rupatadine with grape fruit juice is not recommended.

Interaction

CYP3A4 inhibitors like Erythromycin & Ketoconazole inhibits both the presystemic and systemic metabolism of Rupatan. Due to this potential interaction, it is not recommended to use Rupatan in combination with Ketoconazole, macrolides or any other inhibitors of CYP3A4. Co administration of Rupatan and CNS depressants or alcohol may increase CNS depressant effect.

Food Interaction

  • Avoid grapefruit products. Grapefruit inhibits CYP3A metabolism, which may increase the serum concentration of rupatadine.
  • Take with or without food.

Volume of Distribution

The apparent volume of distribution is 9799 L .

Elimination Route

Rupatidine is rapidly absorbed with a Tmax of 1 h . Administration with a high fat meal increases exposure by 23% and increases Tmax to 2 h.

Half Life

The half life of elimination is 15.9 h in children 2-5 years old, 12.3 h in children 6-11 years old, 5.9 h in adults, and 8.7 h in geriatric patients .

Clearance

Systemic clearance is 1556.2 L/h in young adults and 798.2 L/h in geriatric patients .

Pregnancy & Breastfeeding use

Pregnancy category B2 (by TGA, Australia). There is no clinical data available on the exposure of Rupatan during pregnancy. Pregnant women should therefore not use Rupatan, unless the potential benefit outweighs the potential risk for the fetus. No information is available, whether Rupatan is excreted in the mother's milk. Therefore, it should not be used during lactation, unless the potential benefits for the mother justify the potential risk to the infant.

Contraindication

Hypersensitivity to Rupatan or to any of the excipients.

Special Warning

Elderly: Rupatan should be used with caution in elderly. No information is available that indicates the requirement of any dose adjustment in this population.

Children: Neither the safety nor the efficacy of Rupatan has been established in patients less than 12 years of age.

Patients with renal or hepatic insufficiency: Use of Rupatan is not recommended in patients with renal or hepatic insufficiency. As no relevant clinical data is available.

Innovators Monograph

You find simplified version here Rupatan

Rupatan contains Rupatadine see full prescribing information from innovator Rupatan Monograph, Rupatan MSDS, Rupatan FDA label

FAQ

What is Rupatan used for?

Rupatan is also used to relieve the symptoms associated with urticaria such as itching and hives (localised skin redness and swelling).

How safe is Rupatan?

Rupatan has been found to be effective and safe Iin a variety of randomized clinical trials both in both seasonal and perennial allergic rhinitis, as well as inbut also chronic urticaria Rupatadine has been found as effective and safe.

How does Rupatan work?

Rupatan works by blocking the action of one of the body's natural chemicals known as histamine.

What are the common side effects of Rupatan?

Common side effects of Rupatan are Sleepiness, headache, dizziness, dry mouth, sensation of weakness and fatigue.

Is Rupatan safe during pregnancy?

Rupatan is preferable to avoid the use of rupatadine during pregnancy.

Is Rupatan safe during breastfeeding?

Rupatan is excreted in animal milk. It is unknown whether Rupatan is excreted into breast milk. A decision must be made whether to discontinue breastfeeding or to discontinue/abstain from Rupatan therapy taking into account the benefit of breastfeeding for the child and the benefit of therapy for the woman.

Can I drink alcohol with Rupatan?

Drink of alcohol is not recommended during treatment with this medicine due to the increased risk of severe adverse effects.

How long does it take for Rupatan to work?

Rupatan usually starts working within 2 hours and lasts for 24 hours.

How long does Rupatan stay in my system?

The mean elimination half-life of Rupatan in elderly and young volunteers was 8.7 hours and 5.9 hours respectively.

Is Rupatan a sedative?

Rupatan is a second generation, non-sedating, long-acting histamine antagonist with selective peripheral H1 receptor antagonist activity.

Does Rupatan make I sleepy?

This drug may make you drowsy.Talk to your doctor about using Rupatan safely.

Can I drive after taking Rupatan?

At the recommended dosage, Rupatan is not expected to influence your ability to drive or use machinery.

Is Rupatan an anti inflammatory?

Rupatan has a dual anti inflammatory effect by blocking both histamine H1 and PAF receptors.

Can I take Rupatan for a long time?

Rupatan 10 and 20mg once-daily doses were well tolerated in long-term use.

How long can you take Rupatan?

All patients received Rupatan 10 mg/day and were allowed to continue their normal concomitant medication for all conditions, other than rhinitis, for up to 6 or 12 months.

Is Rupatan a mast cell stabilizer?

Rupatan can inhibit histamine and cytokine secretion from human mast cells in response to allergic, immune and neuropeptide triggers.

What happens if I miss a dose?

If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

How effective is Rupatan for kindney?

The safety and effectiveness of Rupatan have not been established for people with reduced kidney function. Rupatan is not recommended for people with reduced kidney function.

How effective is Rupatan for liver?

The safety and effectiveness of Rupatan have not been established for people with reduced liver function. Rupatan  is not recommended for people with reduced liver function.

*** Taking medicines without doctor's advice can cause long-term problems.
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