Rimexolon

Rimexolon Uses, Dosage, Side Effects, Food Interaction and all others data.

Rimexolon is a glucocorticoid receptor agonist. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition of arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. By binding to the glucocorticoid receptor, this drug ultimately leads to changes in genetic transcription involving the lipocortins and prostaglandins.

Rimexolon is a glucocorticoid corticosteroid for systemic use. Corticosteroids suppress the inflammatory response to a variety of inciting agents of a mechanical, chemical, or immunological nature. They inhibit edema, cellular infiltration, capillary dilatation, fibroblastic proliferation, deposition of collagen and scar formation associated with inflammation.

Trade Name Rimexolon
Generic Rimexolone
Rimexolone Other Names Rimexolon, Rimexolona, Rimexolone
Type
Formula C24H34O3
Weight Average: 370.533
Monoisotopic: 370.250794955
Groups Approved
Therapeutic Class Ophthalmic Steroid preparations
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Rimexolon
Rimexolon

Uses

Rimexolon ophthalmic suspension is used for the treatment of postoperative inflammation following ocular surgery and in the treatment of anterior uveitis.

Rimexolon is also used to associated treatment for these conditions: Anterior Uveitis (AU), Ocular Inflammation

How Rimexolon works

Rimexolon is a glucocorticoid receptor agonist. The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition of arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. By binding to the glucocorticoid receptor, this drug ultimately leads to changes in genetic transcription involving the lipocortins and prostaglandins.

Dosage

Rimexolon dosage

Post-Operative Inflammation: Apply one to two drops of Rimexolon1% Ophthalmic Suspension into theconjunctivalsac of the affected eye four times daily beginning 24 hours after surgery and continuing throughout the first 2 weeks of the postoperative period.

Anterior Uveitis: Apply one to two drops of Rimexolon1% Ophthalmic Suspension into the conjunctival sac of the affected eye every hour during waking hours for the first week, one drop every two hours during waking hours of the second week, and then taper until uveitis is resolved.

Side Effects

Reactions associated with ophthalmic steroids include elevated intraocular pressure, which may be associated with optic nerve damage, visual acuity and field defects, posterior subcapsular cataract formation, secondary ocular infection from pathogens including herpes simplex, and perforation of the globe where there is thinning of the cornea or sclera.

Ocular adverse reactions occurring in 1 - 5% of patients in clinical studies of Rimexolon 1% (rimexolone ophthalmic suspension) included blurred vision, discharge, discomfort, ocular pain, increased intraocular pressure, foreign body sensation, hyperemia and pruritus.

Other ocular adverse reactions occurring in less than 1% of patients included sticky sensation, increased fibrin, dry eye, conjunctival edema, corneal staining, keratitis, tearing, photophobia, edema, irritation, corneal ulcer, browache, lid margin crusting, corneal edema, infiltrate, and corneal erosion.

Non-ocular adverse reactions occurred in less than 2% of patients. These included headache, hypotension, rhinitis, pharyngitis, and taste perversion.

Toxicity

Symptoms of overdose include retinal toxicity, glaucoma, and subcapsular cataract.

Precaution

Fungal infections of the cornea are particularly prone to develop coincidentally with long-term local steroid application. Fungal invasion must be considered in any persistent corneal ulceration where a steroid has been or is in use.

For ophthalmic use only. Use of the same bottle for both eyes is not recommended with topical eye drops that are used in association with surgery.

The initial prescription and renewal of the medication order beyond 14 days should be made by a physician only after examination of the patient with the aid of magnification, such as slit lamp biomicroscopy and where appropriate, fluorescein staining. If signs and symptoms fail to improve after two days, the patient should be reevaluated. If this product is used for 10 days or longer,intraocular pressure should be monitored even though it may be difficult in children and uncooperative patients

Interaction

No information provided

Food Interaction

No interactions found.

Elimination Route

Systemically absorbed.

Half Life

The serum half-life of rimexolone could not be reliably estimated due to the large number of samples below the quantitation limit of the assay (80 pg/mL). However, based on the time required to reach steady-state, the half-life appears to be short (1-2 hours).

Elimination Route

Following IV administration of radio-labelled rimexolone to rats, greater than 80% of the dose is excreted via the feces as rimexolone and metabolites.

Pregnancy & Breastfeeding use

Pregnancy Category C. Rimexolon has been shown to be teratogenic and embryotoxic in rabbits following subcutaneous administration at the lowest dose tested (0.5 mg/kg/day, approximately 2 times the recommended human ophthalmic dose). Corticosteroids are recognized to cause fetal resorptions and malformations in animals. There are no adequate and well-controlled studies in pregnant women. Rimexolon 1% (rimexolone ophthalmic suspension) should be used in pregnant women only if the potential benefit to the mother justifies the potential risk to the fetus.

Nursing Mothers: It is not known whether topical ophthalmic administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in human breast milk. Nevertheless, caution should be exercised when topical corticosteroids are administered to a nursing woman; a decision should be made whether to discontinue nursing or discontinue therapy, taking into consideration the importance of the drug to the mother.

Contraindication

Rimexolon 1% (rimexolone ophthalmic suspension) is contraindicated in epithelial herpes simplex keratitis (dendritic keratitis), vaccinia, varicella, and most other viral diseases of the cornea and conjunctiva; mycobacterial infection of the eye; fungal diseases of the eye; acute purulent untreated infections which, like other diseases caused by microorganisms, may be masked or enhanced by the presence of the steroid; and in those persons with hypersensitivity to any component of the formulation.

Special Warning

Pediatric Use: Safety and effectiveness in pediatric patients have not been established.

Geriatric Use: No overall differences in safety or effectiveness have been observed between elderly and younger patients.

Storage Condition

Store upright between 2-25° C. Do not freeze. Shake well before use.

Innovators Monograph

You find simplified version here Rimexolon

Rimexolon contains Rimexolone see full prescribing information from innovator Rimexolon Monograph, Rimexolon MSDS, Rimexolon FDA label

FAQ

What is Rimexolon used for?

Rimexolon is used to treat eye inflammation caused by infections, injury, surgery, or other conditions.Rimexolon prevents the release of substances in the body that cause inflammation.

How safe is Rimexolon?

Rimexolon 1% ophthalmic suspension is safe and effective for the treatment of uveitis.

How does Rimexolon work?

Rimexolon works by relieving symptoms such as swelling and redness.

What are the common side effects of Rimexolon?

Common side effects of Rimexolon are include:

  • Blurred vision or other change in vision
  • eye discharge, discomfort, dryness, or tearing
  • eye redness, irritation, or pain
  • feeling of something in the eye
  • itching
  • sore throat
  • stuffy or runny nose
  • swelling of the lining of the eyelids

Is Rimexolon safe during pregnancy?

There have been no adequate studies conducted into the safe use of Rimexolon in pregnant women, It should only be used when the potential benefits to the mother outweigh possible risk to the fetus.

Is Rimexolon safe during breastfeeding?

Ophthalmic Rimexolon would not be expected to cause any adverse effects in breastfed infants.

How can I used Rimexolon?

The usual dose of Rimexolon ophthalmic is 1 or 2 drops into each affected eye.

How often can I take Rimexolon?

Adults use one or two drops in the affected eye four times a day beginning twenty-four hours after surgery and continuing throughout the first two weeks after surgery. Children use and dose must be determined by your doctor.

Who should not take Rimexolon?

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

What happen If I missed Rimexolon?

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

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*** Taking medicines without doctor's advice can cause long-term problems.
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