Propoxycaine

Propoxycaine Uses, Dosage, Side Effects, Food Interaction and all others data.

Propoxycaine is a local anesthetic of the ester type that has a rapid onset of action and a longer duration of action than procaine hydrochloride . This drug was removed from the US market in 1996. Although no longer available in the United States, this medication was used in combination with procaine to aid in anesthesia during dental procedures . Used in combination with procaine, it was the only dental local anesthetic available in cartridge form .

Propoxycaine is a local anesthetic which acts to decrease nerve impulses and therefore pain sensation during dental procedures .

Propoxycaine
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Propoxycaine
Generic	Propoxycaine
Propoxycaine Other Names	Propoxycaine
Type
Formula	C₁₆H₂₆N₂O₃
Weight	Average: 294.395 Monoisotopic: 294.194342705
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Propoxycaine is a local anesthetic medication. It was used beginning in the 1950s during dental procedures . It has been combined with procaine to accelerate its onset of action and provide longer-lasting anesthetic effect .

It was produced for use when amide local anesthetics were contraindicated due to allergy or when several amide anesthetics were unsuccessful .

How Propoxycaine works

Propoxycaine is a para-aminobenzoic acid ester with local anesthetic activity. Propoxycaine binds to and blocks voltage-gated sodium channels, thereby inhibiting the ionic flux essential for the conduction of nerve impulses. This results in a loss of sensation .

In one study, propoxycaine hydrochloride increased annular lipid fluidity in cell lipid bilayers and had a greater fluidizing effect on the inner monolayer than that of the outer monolayer . This may further confirm its role in modulating neural impulses.

Toxicity

The toxicity of this medication (7-8 times higher than that of procaine), has prevented this medication from being used on its own .

Ester-type local anesthetics are much more likely to cause an allergic reaction compared to the amide-group local anesthetics because of the formation of PABA (Para-aminobenzoic acid) during the metabolic process. PABA may cause allergic reactions that range from urticaria to anaphylaxis. PABA is also formed during the metabolism of methylparaben (a common preservative) that is normally found in multi-dose vials including lidocaine (MDV) (amide-type local anesthetic) .