ProHance

Uses

ProHance is a medication used to improve the contrast of MRI scans for better visualization.

ProHance is an MRI contrast agent used for contrast enhancement of the brain, spine and surrounding tissues resulting in improved visualization (compared with unenhanced MRI) of lesions with abnormal vascularity or those thought to cause a disruption of the normal blood brain barrier. ProHance can also be used for whole body contrast enhanced MRI including the head, neck, liver, breast, musculoskeletal system and soft tissue pathologies.

ProHance is also used to associated treatment for these conditions: Abnormal vascularity of the brain, Abnormal vascularity of the spine, Lesions in the head and neck

How ProHance works

Based on the behavior of protons when placed in a strong magnetic field, which is interpreted and transformed into images by magnetic resonance (MR) instruments. Paramagnetic agents have unpaired electrons that generate a magnetic field about 700 times larger than the proton's field, thus disturbing the proton's local magnetic field. When the local magnetic field around a proton is disturbed its relaxation process is altered. MR images are based on proton density and proton relaxation dynamics. MR instruments can record two different relaxation processes, the T1 (spin-lattice or longitudinal relaxation time) and T2 (spin-spin or transverse relaxation time). In MRI, visualization of normal and pathological brain tissue depends in part on variations in the radiofrequency signal intensity that occur with changes in proton density, alteration of the T1, and variation in T2. When placed in a magnetic field, gadoteridol shortens the T1 relaxation time in tissues where it accumulates. ProHance does not cross the intact blood-brain barrier; therefore, it does not accumulate in normal brain tissue or in central nervous system (CNS) lesions that have not caused an abnormal blood-brain barrier (e.g., cysts, mature post-operative scars). Abnormal vascularity or disruption of the blood-brain barrier allows accumulation of gadoteridol in lesions such as neoplasms, abscesses, and subacute infarcts.

Food Interaction

ProHance Hypertension interaction

[Major] Gadolinium- based contrast agents (GBCAs) such as gadopentetate dimeglumine, gadoteridol and gadodiamide are contraindicated in patients with chronic, severe kidney disease (glomerular filtration rate, GFR 60 years, hypertension or diabetes).

Always estimate the glomerular filtration rate (GFR) through laboratory testing.

ProHance Drug Interaction

Moderate: metoprolol, metoprololUnknown: charcoal, charcoal, epinephrine, epinephrine, fremanezumab, fremanezumab, orlistat, orlistat, sulfamethoxazole / trimethoprim, sulfamethoxazole / trimethoprim, ubiquinone, ubiquinone, acetaminophen, acetaminophen, cyanocobalamin, cyanocobalamin, cholecalciferol, cholecalciferol

ProHance Disease Interaction

Major: renal impairmentModerate: hemolytic anemia, hepatic impairment, seizures, allergies

Volume of Distribution

• 204 ± 58 mL/kg

Half Life

Distribution 12 minutes (mean), elimination 100 minutes (mean).

Clearance

• 1.50+/- 0.35 mL/ min/kg
• renal cl=1.41 +/- 0.33 mL/ min/kg

Elimination Route

ProHance is eliminated in the urine with 94.4 ± 4.8% (mean ± SD) of the dose excreted within 24 hours post-injection.

Innovators Monograph

You find simplified version here ProHance