Prilocainum

Prilocainum Uses, Dosage, Side Effects, Food Interaction and all others data.

A local anesthetic that is similar pharmacologically to lidocaine. Currently, it is used most often for infiltration anesthesia in dentistry. (From AMA Drug Evaluations Annual, 1992, p165)

Prilocainum binds to the intracellular surface of sodium channels which blocks the subsequent influx of sodium into the cell. Action potential propagation and never function is, therefore, prevented. This block is reversible and when the drug diffuses away from the cell, sodium channel function is restored and nerve propagation returns.

Trade Name Prilocainum
Availability Discontinued
Generic Prilocaine
Prilocaine Other Names Prilocain, Prilocaina, Prilocaïne, Prilocaine, Prilocaine base, Prilocainum, Propitocaine
Type
Formula C13H20N2O
Weight Average: 220.3107
Monoisotopic: 220.157563272
Protein binding

98%

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Prilocainum
Prilocainum

Uses

Prilocainum is a local anesthetic used in dental procedures.

Used as a local anaesthetic and is often used in dentistry.

Prilocainum is also used to associated treatment for these conditions: Local anesthesia therapy

How Prilocainum works

Prilocainum acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. The antiarrhythmic actions are mediated through effects on sodium channels in Purkinje fibers.

Food Interaction

  • Take separate from meals. This is only required when prilocaine is used in the mouth, as it may cause numbness, which can cause bite injury when eating.

Elimination Route

Prilocainum is metabolized in both the liver and the kidney and excreted via the kidney.

Innovators Monograph

You find simplified version here Prilocainum

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0000264
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http://classyfire.wishartlab.com/tax_nodes/C0001663
http://classyfire.wishartlab.com/tax_nodes/C0002228
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0001831
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:8404
http://www.hmdb.ca/metabolites/HMDB0014888
http://www.genome.jp/dbget-bin/www_bget?drug:D00553
http://www.genome.jp/dbget-bin/www_bget?cpd:C07531
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4906
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46505066
https://www.chemspider.com/Chemical-Structure.4737.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225477
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=8686
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=8404
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1194
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000511
http://www.pharmgkb.org/drug/PA451101
https://en.wikipedia.org/wiki/Prilocaine
*** Taking medicines without doctor's advice can cause long-term problems.
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