Pipobroman
Pipobroman Uses, Dosage, Side Effects, Food Interaction and all others data.
An antineoplastic agent that acts by alkylation.
Pipobroman is an antineoplastic agent. Specifically it is a piperazine derivative with a chemical structure close to that of many DNA alkylating agents. Pipobroman has well documented clinical activity against polycythemia vera and essential thrombocythemia.
| Trade Name | Pipobroman |
| Generic | Pipobroman |
| Pipobroman Other Names | Pipobroman, Pipobromanum |
| Type | |
| Formula | C10H16Br2N2O2 |
| Weight | Average: 356.054 Monoisotopic: 353.95785306 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the treatment of polycythaemia vera and refractory chronic myeloid leukaemia.
How Pipobroman works
The mechanism of action is uncertain but pipobroman is thought to alkylate DNA leading to disruption of DNA synthesis and eventual cell death.
Toxicity
Symptoms of overdose include hematologic toxicity, especially with chronic overdosage.
Elimination Route
Well absorbed from the GI tract.
Innovators Monograph
You find simplified version here Pipobroman
