Orciprenaline

Orciprenaline Uses, Dosage, Side Effects, Food Interaction and all others data.

A beta-adrenergic agonist used in the treatment of asthma and bronchospasms. [PubChem]

Orciprenaline (also known as metaproterenol), a synthetic amine, is structurally and pharmacologically similar to isoproterenol. Orciprenaline is used exclusively as a bronchodilator. The pharmacological effects of beta adrenergic agonist drugs, such as orciprenaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3',5'- adenosine monophosphate (c-AMP). Increased cAMP levels lead to relaxation of bronchial smooth muscles and inhibition of the release of inalammatory mediators from mast cells that are involved in promoting immediate hypersensitivity .

Trade Name Orciprenaline
Generic Orciprenaline
Orciprenaline Other Names Metaproterenol, Orciprenalina, Orciprenaline, Orciprenalinum
Type
Formula C11H17NO3
Weight Average: 211.2576
Monoisotopic: 211.120843415
Groups Approved
Therapeutic Class
Manufacturer
Available Country Canada, United States
Last Updated: September 19, 2023 at 7:00 am
Orciprenaline
Orciprenaline

Uses

Orciprenaline is a beta-2 adrenergic agonist used to treat bronchospasm, asthma, and COPD.

For the treatment of bronchospasm, chronic bronchitis, asthma, and emphysema.

Orciprenaline is also used to associated treatment for these conditions: Asthma, Bronchospasm, Chronic Bronchitis, Pulmonary Emphysema

How Orciprenaline works

Orciprenaline stimulates the β2-adrenergic receptor expressed in the lungs, uterus, and vasculature supplying skeletal muscles by acting as a moderately selective agonist. It exerts minimal or no effect on alpha-adrenergic receptors. Intracellularly, the actions of orciprenaline are mediated by cAMP, the production of which is augmented by beta stimulation. The drug is believed to work by activating adenylate cyclase, the enzyme responsible for producing the cellular mediator cAMP.

Toxicity

Symptoms of overdose include angina, hypertension or hypotension, arrhythmias, nervousness, headache, tremor, dry mouth, palpitation, nausea, dizziness, fatigue, malaise and insomnia. LD50=42 mg/kg (orally in rat).

Food Interaction

  • Limit caffeine intake.
  • Take with or without food. The absorption is unaffected by food.

Elimination Route

3% (oral bioavailability of 40%)

Half Life

6 hours

Innovators Monograph

You find simplified version here Orciprenaline

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0002448
http://classyfire.wishartlab.com/tax_nodes/C0000134
http://classyfire.wishartlab.com/tax_nodes/C0001286
http://classyfire.wishartlab.com/tax_nodes/C0000137
http://classyfire.wishartlab.com/tax_nodes/C0003899
http://classyfire.wishartlab.com/tax_nodes/C0004647
http://classyfire.wishartlab.com/tax_nodes/C0004646
http://classyfire.wishartlab.com/tax_nodes/C0002279
http://classyfire.wishartlab.com/tax_nodes/C0001661
http://classyfire.wishartlab.com/tax_nodes/C0001897
http://classyfire.wishartlab.com/tax_nodes/C0002228
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0003073
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:6792
http://www.hmdb.ca/metabolites/HMDB0014954
http://www.genome.jp/dbget-bin/www_bget?drug:D00685
http://www.genome.jp/dbget-bin/www_bget?cpd:C07144
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4086
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504464
https://www.chemspider.com/Chemical-Structure.3944.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50295572
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=7688
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=83329
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL776
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DNC000927
http://www.pharmgkb.org/drug/PA450390
http://www.rxlist.com/cgi/generic2/metaproterenol.htm
https://en.wikipedia.org/wiki/Orciprenaline
*** Taking medicines without doctor's advice can cause long-term problems.
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