Nimenrix 0.5 ml/prefilled syringe IM Injection Uses, Dosage, Side Effects and more

After reconstitution, 1 dose (0.5 ml) contains: Neisseria meningitidis group A polysaccharide 1 5 micrograms Neisseria meningitidis group C polysaccharide 1 5 micrograms Neisseria meningitidis group W-135 polysaccharide 1 5 micrograms Neisseria meningitidis group Y polysaccharide 1 5 micrograms Anti-capsular meningococcal antibodies protect against meningococcal diseases via complement mediated bactericidal activity. Nimenrix 0.5 ml/prefilled syringe IM Injection induces the production of bactericidal antibodies against capsular polysaccharides of Neisseria meningitidis group A,C,W-135 and Y when measured by assays using either rSBA or hSBA.

Attribute	Details
Trade Name	Nimenrix 0.5 ml/prefilled syringe IM Injection
Generic	Meningococcal Conjugate Vaccine
Weight	0.5 ml/prefilled syringe
Type	IM Injection
Therapeutic Class	Vaccines, Anti-sera & Immunoglobulin
Manufacturer	Radiant Pharmaceuticals Ltd. (Mfg. by: Pfizer)
Available Country	Bangladesh
Last Updated:	January 7, 2025 at 1:49 am

Uses

Nimenrix 0.5 ml/prefilled syringe IM Injection is used for active immunisation of individuals from the age of 6 weeks against invasive meningococcal diseases caused by Neisseria meningitidis group A, C, W-135, and Y.

Dosage

Posology: Nimenrix 0.5 ml/prefilled syringe IM Injection should be used in accordance with available official recommendations. Primary immunisation:

Infants from 6 weeks to less than 6 months of age: two doses, each of 0.5 ml, should be administered with an interval of 2 months between doses.
Infants from 6 months of age, children, adolescents and adults: a single 0.5 mL doseshould be administered.
An additional primary dose of Nimenrix 0.5 ml/prefilled syringe IM Injection may be considered appropriate for some individuals.

Booster doses: After completion of the primary immunisation course in infants 6 weeks to less than 12 months of age, a booster dose should be given at 12 months of age with an interval of at least 2 months after the last Meningococcal Conjugate vaccination. In previously vaccinated individuals 12 months of age and older, Nimenrix 0.5 ml/prefilled syringe IM Injection may be given as a booster dose if they have received primary vaccination with a conjugated or plain polysaccharide meningococcal vaccine.

Immunisation should be carried out by intramuscular injection only. In infants, the recommended injection site is the anterolateral aspect of the thigh. In individuals from 1 year of age, the recommended injection site is the anterolateral aspect of the thigh or the deltoid muscle. For instructions on reconstitution of the medicinal product before administration.

Side Effects

Adverse reactions are Appetite lost, Irritability, Insomnia, Crying, Drowsiness, Headache, Hypoaesthesia, Dizziness, Diarrhoea, Vomiting, Nausea, Pruritus, Rash, Myalgia, Pain in extremity, Fever, Swelling at injection site, Pain at injection site, Redness at injection site, Fatigue, Injection site haematoma, Malaise, Injection site induration, Injection site pruritus, Injection site warmth, Injection site anaesthesia

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Interaction

In infants, Nimenrix 0.5 ml/prefilled syringe IM Injection can be given concomitantly with combined DTaP-HBV-IPV/Hib vaccines and with 10-valent pneumococcal conjugate vaccine.
From age 1 year and above, Nimenrix 0.5 ml/prefilled syringe IM Injection can be given concomitantly with any of the following vaccines: hepatitis A (HAV) and hepatitis B (HBV) vaccines, measles- mumps-rubella (MMR) vaccine, measles- mumps- rubella- varicella (MMRV) vaccine, 10-valent pneumococcal conjugate vaccine or unadjuvanted seasonal influenza vaccine.
In the second year of life, Nimenrix 0.5 ml/prefilled syringe IM Injection can also be given concomitantly with combined diphtheria- tetanus- acellular pertussis (DTaP) vaccines, including combination DTaP vaccines with hepatitis B, inactivated poliovirus or Haemophilus influenzae type b (HBV, IPV or Hib) such as DTaP-HBV-IPV/Hib vaccine, and 13-valent pneumococcal conjugate vaccine.
In individuals aged 9 to 25 years, Nimenrix 0.5 ml/prefilled syringe IM Injection can be given concomitantly with human papillomavirus bivalent [Type 16 and 18] vaccine, recombinant (HPV2).
Whenever possible, Nimenrix 0.5 ml/prefilled syringe IM Injection and a TT containing vaccine, such as DTaP-HBV-IPV/Hib vaccine, should be co-administered or Nimenrix 0.5 ml/prefilled syringe IM Injection should be administered at least one month before the TT containing vaccine.
One month after co-administration with a 10-valent pneumococcal conjugate vaccine, lower Geometric Mean antibody Concentrations (GMCs) and opsonophagocytic assay (OPA) antibody GMTs were observed for one pneumococcal serotype (18C conjugated to tetanus toxoid carrier protein). The clinical relevance of this observation is unknown.
There was no impact of co-administration on immune responses to the other nine pneumococcal serotypes.
One month after co-administration with a combined tetanus toxoid, reduced diphtheria toxoid and acellular pertussis vaccine, adsorbed (Tdap) in subjects aged 9 to 25 years, lower GMCs were observed to each pertussis antigen (pertussis toxoid [PT], filamentous haemagglutinin [FHA] and pertactin [PRN]). More than 98% of subjects had anti-PT, FHA or PRN concentrations above the assay cut-off thresholds. The clinical relevance of these observations is unknown. There was no impact of co-administration on immune responses to Nimenrix 0.5 ml/prefilled syringe IM Injection or the tetanus or diphtheria antigens included in Tdap.
If Nimenrix 0.5 ml/prefilled syringe IM Injection is to be given at the same time as another injectable vaccine, the vaccines should always be administered at different injection sites.
It may be expected that in patients receiving immunosuppressive treatment, an adequate response may not be elicited.

Pregnancy & Breastfeeding use

Pregnancy: There is limited experience with use of Nimenrix 0.5 ml/prefilled syringe IM Injection in pregnant women. Animal studies do not indicate direct or indirect harmful effects with respect to pregnancy, embryo/foetal development, parturition or post-natal development. Nimenrix 0.5 ml/prefilled syringe IM Injection should be used during pregnancy only when clearly needed, and the possible advantages outweigh the potential risks for the foetus.

Breast-feeding: It is unknown whether Nimenrix 0.5 ml/prefilled syringe IM Injection is excreted in human milk. Nimenrix 0.5 ml/prefilled syringe IM Injection should only be used during breast-feeding when the possible advantages outweigh the potential risks.