NeoMercazole Uses, Dosage, Side Effects, Food Interaction and all others data.

NeoMercazole is metabolised to thiamazole which is responsible for its antithyroid action. It blocks the production of thyroid hormones through inhibition of the organification of iodide and the coupling of iodothyronine residues.

NeoMercazole is a carbethoxy derivative of methimazole. Its antithyroid action is due to its conversion to methimazole after absorption. It is used to treat hyperthyroidism and thyrotoxicosis.

Trade Name NeoMercazole
Generic Carbimazole
Carbimazole Other Names Athyromazole, Carbethoxymethimazole, Carbimazol, Carbimazole, Carbimazolo, Carbimazolum, Carbinazole
Weight 5mg,
Type Tablet
Formula C7H10N2O2S
Weight Average: 186.232
Monoisotopic: 186.046298264
Protein binding


Groups Approved, Investigational
Therapeutic Class Anti-thyroid drugs
Manufacturer Advanz Pharma, Lesanto Laboratories Ltd
Available Country United Kingdom, India, Nigeria,
Last Updated: September 19, 2023 at 7:00 am


NeoMercazole is used for the management of hyperthyroidism, thyrotoxicosis (including thyroid storm), and also for the preparation of patients for thyroidectomy. NeoMercazole can also be used in combination with radio-active ablative therapy

NeoMercazole is also used to associated treatment for these conditions: Hyperthyroidism

How NeoMercazole works

NeoMercazole is an aitithyroid agent that decreases the uptake and concentration of inorganic iodine by thyroid, it also reduces the formation of di-iodotyrosine and thyroxine. Once converted to its active form of methimazole, it prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4.


NeoMercazole dosage

10 mg to 60 mg daily according to the severity of the disorder. The dose should be gradually reduced to the smallest amount which will control the disease. Daily dosage should be divided.

Side Effects

Nausea, headache, arthralgia, fever, jaundice, malaise, mild gastric distress, skin rashes, pruritus, taste disturbance; bone marrow depression including neutropenia, eosinophilia, leucopenia. Rarely, pancytopenia/aplastic anaemia and isolated thrombocytopenia, haemolytic anaemia.


Caution should be taken in patients with intrathoracic goitre. Mild to moderate hepatic impairment. Caution also should be taken in children, pregnancy and lactation.


NeoMercazole may interact adversely with other medicines. Iodine or iodine excess may decrease the response to NeoMercazole, requiring an increase in dosage or longer duration of therapy with antithyroid agents. As thyroid and metabolic status of patient decreases toward normal, response to oral anticoagulants may decrease, however, if thioamide-induced hypoprothrombinemia occurs, anticoagulant effects may be enhanced. Adjustment of oral anticoagulant dosage on the basis of prothrombin time is recommended. Serum concentrations of digoxin and digitoxin have been reported to increase as the thyroid and metabolic status of patients taking antithyroid agents decreased, reduction in dosage of any digitalis glycoside may be necessary as patients become euthyroid.

Pregnancy & Breastfeeding use

Pregnancy Category D. There is positive evidence of human foetal risk, but the benefits from use in pregnant women may be acceptable despite the risk


Hypersensitivity to carbimazole or other thiourea antithyroid agents

Acute Overdose

Overdose or accidental poisoning may result in hypothyroidism and goitre. If blood dyscrasias occur, the drug should be immediately withdrawn. Further treatment is symptomatic and supportive.

Storage Condition

Store below 25° C.

Innovators Monograph

You find simplified version here NeoMercazole

NeoMercazole contains Carbimazole see full prescribing information from innovator NeoMercazole Monograph, NeoMercazole MSDS, NeoMercazole FDA label

*** Taking medicines without doctor's advice can cause long-term problems.