Nazdec

Nazdec Uses, Dosage, Side Effects, Food Interaction and all others data.

Nazdec blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.

Nazdec is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Nazdec has not been shown effective in the management of behaviorial complications in patients with mental retardation.

Trade Name Nazdec
Availability Prescription only
Generic Fluphenazine
Fluphenazine Other Names Flufenazina, Fluorfenazine, Fluorophenazine, Fluorphenazine, Fluphenazin, Fluphénazine, Fluphenazine, Fluphenazinum, Triflumethazine
Related Drugs haloperidol, prochlorperazine, Haldol, Compazine, chlorpromazine, Thorazine
Type Injection
Formula C22H26F3N3OS
Weight Average: 437.522
Monoisotopic: 437.174867774
Groups Approved
Therapeutic Class Phenothiazine drugs
Manufacturer Gentech Healthcare Ltd
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Nazdec
Nazdec

Uses

In the long-term management of psychotic disorders including:

  • Schizophrenia
  • Mania and
  • Organic brain syndrome.

Nazdec is also used to associated treatment for these conditions: Chorea, Depression, Gilles de la Tourette's Syndrome, Psychosis, Sedation

How Nazdec works

Nazdec blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.

Dosage

Nazdec dosage

Nazdec Decanoate by deep intramuscular injection into the gluteal muscle, test dose 12.5 mg (6.25 mg in elderly), then after 4-7 days 12.5-100 mg repeated at intervals of 14-35 days, adjusted according to response; it is not recommended for children.

Side Effects

The side effects include tardive dyskinesia, sedation, mental confusion; hypotension; hyperprolactinaemia leading to galactorrhoea and amenorrhoea in women; loss of libido, impotence and sterility in males. Also include allergic reactions, cholestatic jaundice, corneal and lens deposists, skin pigmentation. Other potential adverse reactions are agranulocytosis; neuroleptic syndrome.

Precaution

Special precaution should be practiced in presence of convulsive disorders; hepatic, renal, cerebrovascular, respiratory and cardiovascular diseases. Also precaution should be observed in case of phenochromocytoma; bone marrow suppression; elderly or debilitated patients.

Interaction

Nazdec reverses antihypertensive effects of Guanethidine, Methyldopa and Clonidine. It also causes lithium toxicity by interacting with it. Antacids may reduce bioavailability of phenothiazines. Additive CNS depressant effects produced with alcohol, barbiturates, hypnotics, sedatives, opiates and antihistamines.

Food Interaction

  • Avoid alcohol.
  • Take with food. Food reduces irritation.

Nazdec Alcohol interaction

[Moderate] GENERALLY AVOID:

Concurrent use of ethanol and phenothiazines may result in additive CNS depression and psychomotor impairment.

Also, ethanol may precipitate dystonic reactions in patients who are taking phenothiazines.

The two drugs probably act on different sites in the brain, although the exact mechanism of the interaction is not known.



Patients should be advised to avoid alcohol during phenothiazine therapy.

Pregnancy & Breastfeeding use

The safety for the use of Nazdec decanoate during pregnancy has not yet been established; therefore the possible hazards should be weighed against the potential benefits when administering this drug to pregnant patients.

Contraindication

Nazdec Decanoate oily Injection is contraindicated in patients with hypersensitivity to the drug. Also contraindicated in comatose or severely depressed states, blood dyscrasias, liver disease, pregnancy (3rd trimester), lactation.

Storage Condition

Store at 15-30°C.

Innovators Monograph

You find simplified version here Nazdec

Nazdec contains Fluphenazine see full prescribing information from innovator Nazdec Monograph, Nazdec MSDS, Nazdec FDA label

*** Taking medicines without doctor's advice can cause long-term problems.
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