N-Trimethylglycine

N-Trimethylglycine Uses, Dosage, Side Effects, Food Interaction and all others data.

N-Trimethylglycine is a methyl group donor that functions in the normal metabolic cycle of methionine and reduces homocystinuria in patients with inborn errors of methionine metabolism. In the United States, betaine is distributed under the brand name Cystadane® by Rare Disease Therapeutics. Many reports have shown that betaine's therapeutic effectiveness is limited, and does not lower tHcy levels or prevent clinical symptoms [2].

Trade Name N-Trimethylglycine
Availability Prescription only
Generic Betaine
Betaine Other Names 2-trimethylammonioacetate, Abromine, Acidol, Betaína anhidra, Betaine, Glycine betaine, Glycinebetaine, Glykokollbetain, N,N,N-Trimethylglycine, Trimethylaminoacetate, Trimethylammonioacetate, Trimethylglycine
Type
Formula C5H11NO2
Weight Average: 117.1463
Monoisotopic: 117.078978601
Groups Approved, Nutraceutical
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
N-Trimethylglycine
N-Trimethylglycine

Uses

N-Trimethylglycine is a methyl group donor used for the treatment of homocystinuria to decrease elevated homocysteine blood levels.

N-Trimethylglycine is indicated for the treatment of homocystinuria to decrease elevated homocysteine blood levels. Included within the category of homocystinuria are deficiencies or defects in: 1. cystathionine beta-synthase (CBS), 2. 5,10-methylenetetrahydrofolate reductase (MTHFR), 3. cobalamin cofactor metabolism (cbl).

N-Trimethylglycine is also used to associated treatment for these conditions: Homocystinuria

How N-Trimethylglycine works

N-Trimethylglycine acts as a methyl group donor in the remethylation of homocysteine to methionine in patients with homocystinuria.

Toxicity

In an acute toxicology study in rats, death frequently occurred at doses equal to or greater than 10,000 mg/kg.

Food Interaction

  • Take with or without food. Oral betaine powder should be mixed with food or a beverage and then consumed.

Volume of Distribution

V/F = 1.3 l/kg

Elimination Route

After a single oral dose of betaine (50 mg/kg), absorption was rapid (tmax = 0.9 ± 0.3 hours and a Cmax = 0.9 ± 0.2 mM).

Half Life

14 hours

Clearance

84 ml/h/kg

Innovators Monograph

You find simplified version here N-Trimethylglycine

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http://classyfire.wishartlab.com/tax_nodes/C0002449
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:17750
http://metacyc.org/META/new-image?type=COMPOUND&object=BETAINE
http://www.hmdb.ca/metabolites/HMDB0000043
http://www.genome.jp/dbget-bin/www_bget?drug:D07523
http://www.genome.jp/dbget-bin/www_bget?cpd:C00719
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=247
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=310264879
https://www.chemspider.com/Chemical-Structure.242.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50103520
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=1512
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=17750
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1182
https://www.drugs.com/pro/cystadane.html
https://en.wikipedia.org/wiki/Trimethylglycine
*** Taking medicines without doctor's advice can cause long-term problems.
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