MUCOGEL SUSPENSION

Uses

Heartburn, Indigestion, Gastric Hyperacidity, Peptic ulcer disease, Gastroesophageal reflux disorder (GERD)

MUCOGEL SUSPENSION is also used to associated treatment for these conditions: Acid Reflux, Acid indigestion, Bloating, Colic, Flatulence, Gastric Ulcer, Heartburn, Upset stomach

How MUCOGEL SUSPENSION works

The gelatinous silicon dioxide, formed by the reaction of magnesium trisilicate with gastric contents is said to protect ulcerated mucosal surfaces and favor healing.

Dosage

MUCOGEL SUSPENSION dosage

Adult: Chew 2 to 4 tablets after meals and at bedtime as needed (up to 4 times a day) or as directed by a doctor. For best results, drink a half glass of water or other liquid after each dose. Do not take more than 16 tablets in 24 hours.

Children less than 12 years: Not recommended.

Side Effects

Chalky taste, Constipation, Fecal impaction, Stomach cramps, Nausea, Vomiting, Aluminum intoxication, Hypophosphatemia, Osteomalacia, Magnesium, Diarrhea, Hypermagnesemia.

Toxicity

Adequate doses of magnesium trisilicate may cause diarrhea due to the action of soluble magnesium salts in the enteric tract. Approx 5% of the magnesium is absorbed.

Precaution

Renal dysfunction, low phosphate diet, prolonged use

Interaction

Aluminium Hydroxide: Enhanced absorption with citrates or ascorbic acid. Decreases absorption of allopurinol, tetracyclines, quinolones, cephalosporins, biphosphonate derivatives, corticosteroids, cyclosporin, delavirdine, Fe salts, imidazole antifungals, isoniazid, mycophenolate, penicillamine, phosphate supplements, phenytoin, phenothiazines, trientine.

Magnesium Trisilicate: None well documented.

Volume of Distribution

The hydrated silicon dioxide formed in the stomach and passes into the intestinal track.

Elimination Route

The hydrated silicon dioxide formed in the stomach and passes into the intestinal track where, silica can be partly absorbed.

Half Life

16-20 hours

Clearance

Maximum magnesium clearance is directly proportional to creatinine clearance.

Elimination Route

Excreted in the urine.

Pregnancy & Breastfeeding use

Pregnancy Category-C. Unknown whether distributed in breast milk. Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks

Contraindication

Hypophosphataemia.

Innovators Monograph

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