mivacron
mivacron Uses, Dosage, Side Effects, Food Interaction and all others data.
mivacron is a bisbenzylisoquinolinium based neuromuscular blocker or muscle relaxant. It binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in a block of neuromuscular transmission.
mivacron is a short-acting, nondepolarizing skeletal neuromuscular blocking agent which is hydrolyzed by plasma cholinesterase. mivacron results in a blockade of neuromuscular transmission by binding competitively with cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine. The neuromuscular block produced by mivacurium is readily antagonized by anticholinesterase agents. The deeper the level of neuromuscular block at reversal, the longer the time required for recovery of neuromuscular function and the greater the dose of anticholinesterase agent required. Because spontaneous recovery after mivacurium is rapid, routine reversal may not always result in a clinical benefit.
| Trade Name | mivacron |
| Availability | Prescription only |
| Generic | Mivacurium |
| Mivacurium Other Names | Mivacurium |
| Weight | 2mg/ml, |
| Type | Solution For Injection, Injection |
| Formula | C58H80N2O14 |
| Weight | Average: 1029.2608 Monoisotopic: 1028.560955278 |
| Protein binding | The protein binding of mivacurium has not been determined due to its rapid hydrolysis by plasma cholinesterase. |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | Aspen Pharma Trading Limited |
| Available Country | Saudi Arabia, United Kingdom, United States, Portugal |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
mivacron is a short-acting non-depolarizing neuromuscular blocking agent used to induce anesthesia during intubation and promote skeletal muscle relaxation during surgery or mechanical ventilation.
For inpatients and outpatients, as an adjunct to general anesthesia, to facilitate tracheal intubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
mivacron is also used to associated treatment for these conditions: Curarization therapy, General Anesthesia, Neuromuscular blocking therapy, Facilitation of small bowel intubation therapy, Smooth muscle relaxation prior to radiological procedures
How mivacron works
mivacron binds competitively to cholinergic receptors on the motor end-plate to antagonize the action of acetylcholine, resulting in a block of neuromuscular transmission. This action is antagonized by acetylcholinesterase inhibitors, such as neostigmine.
Toxicity
Overdosage with neuromuscular blocking agents may result in neuromuscular block beyond the time needed for surgery and anesthesia.
Food Interaction
No interactions found.mivacron Drug Interaction
Moderate: dexamethasone, dexamethasone, diltiazem, diltiazem, metoprolol, metoprolol, metoprolol, metoprololUnknown: charcoal, charcoal, sulfamethoxazole / trimethoprim, sulfamethoxazole / trimethoprim, ubiquinone, ubiquinone, copper gluconate, copper gluconate, glucose, glucose, acetaminophen, acetaminophen
mivacron Disease Interaction
Major: prematurity, burns, histamine release, liver disease, myasthenia gravis, paresis, pulmonary impairModerate: obesity, renal dysfunction
Half Life
The mean elimination half-life ranges from 1.7 to 2.6 minutes in healthy, young adults administered 0.1 to 0.25 mg/kg mivacurium. In 9 patients with end-stage liver disease undergoing liver transplant surgery, plasma clearance was approximately 50% lower than that in 8 control patients with normal hepatic function, while the elimination half-life increased to 4.4 minutes from the 1.8 minute control value.
Innovators Monograph
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