Methixen

Methixen Uses, Dosage, Side Effects, Food Interaction and all others data.

Methixen (or methixene) is a anticholinergic used as an antiparkinsonian agent.

Methixen is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Methixen has been discontinued.

Trade Name Methixen
Generic Metixene
Metixene Other Names Methixen, Methixene, Metisene, Metixene, Métixène, Metixeno, Metixenum
Type
Formula C20H23NS
Weight Average: 309.468
Monoisotopic: 309.155120431
Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Methixen
Methixen

Uses

Used for the symptomatic treatment of parkinsonism.

How Methixen works

Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of action of centrally active anticholinergic drugs such as metixene is considered to relate to competitive antagonism of acetylcholine at muscarinic receptors in the corpus striatum, which then restores the balance.

Toxicity

Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.

Elimination Route

Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.

Innovators Monograph

You find simplified version here Methixen

*** Taking medicines without doctor's advice can cause long-term problems.
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