Mecofol Od

Mecofol Od Uses, Dosage, Side Effects, Food Interaction and all others data.

Mecofol Od is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.

Trade Name Mecofol Od
Generic Mecobalamin
Mecobalamin Other Names Co-methylcobalamin, MeCbl, Mecobalamin, Mecobalamina, Mecobalaminum, Methyl vitamin B12, Methyl(III)cobalamin, Methylcobalamin
Type Tablet
Formula C63H91CoN13O14P
Weight Average: 1344.3823
Monoisotopic: 1343.587806391
Groups Approved, Investigational
Therapeutic Class Drugs for Megaloblastic Anemia
Manufacturer Intas Pharmaceuticals Ltd Gx
Available Country India
Last Updated: September 19, 2023 at 7:00 am
Mecofol Od
Mecofol Od


Mecofol Od is used for-

  • Peripheral Neuropathies
  • Diabetic Neuropathy
  • Verteberal Syndrome
  • Nerve Compression Syndrome
  • Multiple sclerosis
  • Amyotrophic lateral sclerosis
  • Parkinson’s disease
  • Alzheimer’s disease
  • Diabetic retinopathy
  • Entrapment neuropathy
  • Drug induced neuropathy
  • Megaloblastic anemia due to Vitamin B12 deficiency

Mecofol Od is also used to associated treatment for these conditions: Vitamin B12 Deficiency, Nutritional supplementation


Mecofol Od dosage

Tablet: The usual adult dosage is one 500 mcg tablet three times daily. The dosage should be adjusted according to the age of patient and the severity of symptoms.


  • Peripheral neuropathies: The usual adult dosage is one ampoule equivalent to 500 mcg of Mecofol Od, administered intramuscularly or intravenously three times a week.The dosage should be adjusted according to the age of patient and the severity of symptoms.
  • Megaloblastic anemia: The usual adult dosage is one ampoule equivalent to 500 mcg of Mecofol Od, administered intramuscularly or intravenously three times a week. After about two months of administration, dosage should be changed to one ampoule equivalent to 500 mcg of Mecofol Od every one to three months as maintenance therapy

Side Effects

Generally Mecofol Od is well tolerated. However, a few side effects like GI discomfort (including anorexia, nausea or diarrhea) & rash may be seen after administration of Mecofol Od.


The medicine should not be used for months if there is no response at all after its use for a certain period of time.


Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol.

Food Interaction

No interactions found.

Pregnancy & Breastfeeding use

Not recommended during pregnancy & lactation.


Hypersensitivity to any component of this product.

Special Warning

Use in children: Not recommended.

Storage Condition

Oral: Store at room temperature. Protect from moisture and light.

Parenteral: Store at room temperature. Do not expose to direct light.

Innovators Monograph

You find simplified version here Mecofol Od


What is Mecofol Od used for?

Mecofol Od is used to treat vitamin B12 deficiency.

How safe is Mecofol Od?

Mecofol Od is considered likely safe when used appropriately.

How does Mecofol Od work?

Mecofol Od works by functioning in the production of a compound called myelin, which covers and protect nerve fibers.

What are the common side effects of Mecofol Od?

Common side effects of Mecofol Od are include:

  • Nausea.
  • Vomiting.
  • Diarrhea.
  • Loss of appetite.
  • Headache.

Is Mecofol Od safe during pregnancy?

Pregnancy There are no data available for Mecofol Od to be used in pregnant women.

Is Mecofol Od safe during breastfeeding?

There are no data available for Mecofol Od to be used in lactating women.

Can I drink alcohol with Mecofol Od?

No interactions were found between Alcohol and Mecofol Od. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Can I take Mecofol Od daily?

The recommended dose is 500 mcg three times daily or 1500 mcg daily. Most generic vitamins contain cyanocobalamin, which may not be as effective or as beneficial.

How much Mecofol Od should I take?

The general recommendation for adults is 2.4 mcg. Older adults, as well as pregnant and breastfeeding women, require higher doses.

Should I take Mecofol Od on an empty stomach?

It is a well-known medical fact that water-soluble vitamins are better absorbed on an empty stomach. So, the usual time of taking Mecofol Od will be in the morning as the first dose, half an hour before lunch, and 2 hours post a meal.

How long does Mecofol Od take to work?

With brisk development of new red blood cells, a response is typically seen within 48 to 72 hours. Mecofol Od supplies have reached normal levels,Mecofol Od injections will be required every one to three months to avoid the return of symptoms.

How long does Mecofol Od supplements stay in my system?

Other studies have shown that Mecofol Od has a half-life of around six days in the blood, which means that it would take six days before half of the administered amount is excreted from the body

Can Mecofol Od damage my liver?

There is no evidence that the other B vitamins, in physiologic or even super-physiologic high doses cause liver injury or jaundice.

What are the symptoms of high Mecofol Od levels?

The study found that high doses of these Mecofol Od were actually harmful.

Can Mecofol Od cause kidney stones?

Mecofol Od have not been shown to be harmful to people with kidney stones.

How long Mecofol Od can be taken?

Mecofol Od for 2-4 weeks is associated with better outcome in nerve conduction velocity and neuropathic symptoms.

Who should not take Mecofol Od?

You should not use Mecofol Od if you are allergic to Mecofol Od or cobalt. Tell your doctor if you have ever had Leber's disease or other form of optic nerve damage,an iron or folic acid deficiency.

What happens if I miss a dose of Mecofol Od?

Use Mecofol Od as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

Can I overdose on Mecofol Od?

You cannot overdose on Mecofol Od because any excess you simply pee out. If you get Mecofol Od shots, you may experience side effects like dizziness, nausea, and fatigue.

*** Taking medicines without doctor's advice can cause long-term problems.