Mb-Tab

Mb-Tab Uses, Dosage, Side Effects, Food Interaction and all others data.

A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Mb-Tab has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia but has largely been superseded by the benzodiazepines. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603) Mb-Tab is a controlled substance in the U.S.

Mb-Tab is an anxiolytic drug. It was the best selling minor tranquilizer for a time but has largely been replaced by benzodiazepines. Mb-Tab has most of the pharmacological effects and dangers of the barbiturates (though it was marketed as being safer) but it is less sedating at effective doses. Mb-Tab exhibits some anticonvulsant effects in absence seizures; however, it is reported to potentially exacerbate generalized tonic-clonic seizures. It has also been used as a hypnotic (sleeping pill). However, its is currently only licensed as an anxiolytic and it is a third or fourth-order choice.

Trade Name Mb-Tab
Availability Prescription only
Generic Meprobamate
Meprobamate Other Names Meprobamat, Meprobamate, Meprobamato, Meprobamatum, Meprobamic acid
Related Drugs escitalopram, alprazolam, duloxetine, Lexapro, Xanax, Cymbalta
Weight 200mg, 400mg
Type Oral, Oral Tablet
Formula C9H18N2O4
Weight Average: 218.2502
Monoisotopic: 218.126657074
Groups Approved, Illicit
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Mb-Tab
Mb-Tab

Uses

Mb-Tab is an anxiolytic drug used for the short-term management of anxiety symptoms.

For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety.

Mb-Tab is also used to associated treatment for these conditions: Anxiety Disorders

How Mb-Tab works

Mb-Tab's mechanism of action is not fully understood; in animal studies, meprobamate is reported to act at multiple sites in the central nervous system, such as the thalamus and limbic system. It binds to the GABAA receptors, leading to inhibitory effects on the neurons transmitting signals in the reticular formation and spinal cord. Consequently, effects such as sedation and altered perception of pain are observed.

Toxicity

Symptoms of overdose include coma, drowsiness, loss of muscle control, severely impaired breathing, shock, sluggishness, and unresponsiveness. There have been a case of death resulting from oral ingestion of 12 g of meprobamate. One case study reports the consumption of 40 g of meprobamate resulting in successful survival.

Food Interaction

  • Avoid alcohol.
  • Take with or without food. Food does not significantly affect absorption.

[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.

Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.

Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

Elimination Route

Well absorbed from the gastrointestinal tract.

Half Life

Plasma half-life is about 10 hours.

Innovators Monograph

You find simplified version here Mb-Tab

*** Taking medicines without doctor's advice can cause long-term problems.
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