Mansil

Mansil Uses, Dosage, Side Effects, Food Interaction and all others data.

An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Mansil causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martidale, The Extra Pharmacopoeia, 31st ed, p121)

Mansil is an anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Mansil causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release egg.

Table Of contents

• Mansil
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Mansil
Availability	Discontinued
Generic	Oxamniquine
Type
Formula	C14H21N3O3
Weight	Average: 279.3348 Monoisotopic: 279.158291553
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

For treatment of Schistosomiasis caused by Schistosoma mansoni

How Mansil works

Mansil may associate with an irreversible inhibition of the nucleic acid metabolism of the parasites. A hypothesis has been put forth that the drug is activated by a single step, in which a schistosome sulfotransferase enzyme converts oxamniquine into an ester (probably acetate, phosphate, or sulfate). Subsequently, the ester spontaneously dissociates, the resulting electrophilic reactant is capable of alkylation of schistosome DNA.

Mansil Drug Interaction

Unknown: aspirin, aspirin, epinephrine, epinephrine, amoxicillin, amoxicillin, RHO Immunoglobulin , RHO Immunoglobulin , mesalamine, mesalamine, azithromycin, azithromycin, ciprofloxacin, ciprofloxacin, dexamethasone, dexamethasone, dextran, low molecular weight, dextran, low molecular weight, heparin, heparin

Mansil Disease Interaction

Moderate: seizure disorders

Elimination Route

Well absorbed orally

Half Life

1-2.5 hours

Innovators Monograph

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