Lulipan Uses, Dosage, Side Effects, Food Interaction and all others data.

Lulipan is a topical antifungal agent. It is a broad-spectrum antifungal agent that belongs to the azole group. It acts against fungus by inhibiting the enzyme lanosterol demethylase and blocks ergosterol synthesis which is an important constituent of fungal cell membrane. Thus it exerts strong fungicidal activity both in-vitro and in-vivo against dermatophytes, Candida albicans, Malassezia spp, Trichophyton and Epidermophyton spp.

Lulipan kills the organisms Trichophyton rubrum and Epidermophyton floccosum, most likely by altering their fungal cell membranes.

Trade Name Lulipan
Generic Luliconazole
Luliconazole Other Names Luliconazole
Type Ww Cream, Cream
Formula C14H9Cl2N3S2
Weight Average: 354.27
Monoisotopic: 352.961495
Protein binding

Plasma protein binding of luliconazole is >99%.

Groups Approved
Therapeutic Class Miscellaneous topical agents
Manufacturer Ipc Healthcare Pvt Ltd, Panzer Pharmaceuticals Pvt Ltd, Curetech Skincare
Available Country India
Last Updated: September 19, 2023 at 7:00 am


Lulipan is used for the topical treatment of interdigital

  • Tinea pedis (athelet's foot),
  • Tinea cruris, and
  • Tinea corporis.

Lulipan is also used to associated treatment for these conditions: Tinea Corporis, Tinea Cruris, Tinea Pedis

How Lulipan works

The exact mechanism of action for luliconazole's anti-fungal activity is still not known, but luliconazole is thought to inhibit the enzyme lanosterol demethylase. Lanosterol demethylase is needed for the synthesis of ergosterol, which is a major component of the fungus cell membranes.


Lulipan dosage


  • Interdigital tinea pedis: Lulipan cream should be applied to the affected area and approximately 1 inch of the immediate surrounding area(s) once daily for two weeks.
  • Tinea cruris and Tinea corporis: Lulipan cream should be applied to the affected area and approximately 1 inch of the immediate surrounding area(s) once daily for one week.
Geriatric: Same as adult
Pediatric: Safety and effectiveness have not been established.

Side Effects

Contact dermatitis and cellulitis may occur. Application site reactions were observed in iess than 1% of subjects in clinical trial.


In clinical trials, no serious toxicity was reported, only local irritation (mild contact dermatitis and cellulitis) at the site of application was found.


If there is any unusual allergic reaction with the use of Lulipan, then treatment should be discontinued and appropriate therapy should be instituted. Lulipan is recommended for topical use only. It is not intended for ophthalmic, oral or intravaginal use.

Food Interaction

No interactions found.

Volume of Distribution

The volume of distribution was not quantified.

Elimination Route

Although luliconazole is administered topically, clinical studies have shown that after the first dose in patients with tina pedis, a maximum plasma concentration of 0.40 ± 0.76 ng/mL (mean ± SD) occurred in 16.9 ± 9.39 hours (mean ± SD).

Half Life

The half life of luliconazole has yet to be determined.


The clearance of luliconazole has yet to be determined.

Elimination Route

The route of elimination of luliconazole has yet to be determined.

Pregnancy & Breastfeeding use

Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Lulipan should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether luliconazole is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Lulipan cream is applied to women who are breastfeeding.



Storage Condition

Do not store above 30°C. Keep away from light and out of the reach of children.

Innovators Monograph

You find simplified version here Lulipan

Lulipan contains Luliconazole see full prescribing information from innovator Lulipan Monograph, Lulipan MSDS, Lulipan FDA label


What is Lulipan used for?

Lulipan is indicated for the treatment of athlete's foot, jock itch, and ringworm caused by dermatophytes such as Trichophyton rubrum, Microsporum gypseum and Epidermophyton floccosum. Lulipan cream is used to treat: Ringworm of the body ; Ringworm of the foot between the toes; and Ringworm of the groin.

How safe is Lulipan?

Lulipan when applied once daily to all 10 fungus-infected toenails for 29 days, is generally safe and well tolerated and results in significant accumulation of drug in the nail.

How does Lulipan work?

Lulipan works by slowing the growth of fungi that cause infection.

What are the common side effects of Lulipan?

Common side effects may include mild skin irritation where the medicine was applied.

Is Lulipan safe during pregnancy?

There are no adequate and well-controlled studies of Lulipan in pregnant women. Lulipan should be used during pregnancy only if the potential benefit justifies the potential risk to the unborn baby.

Is Lulipan safe during breastfeeding?

Lulipan has not been studied during breastfeeding; low risk to the nursing infant expected as this drug is poorly absorbed after topical use and is highly plasma protein bound. Application to the nipple area should be avoided.

Can I drink alcohol with Lulipan?

You can drink alcohol while taking Lulipan.

Can I drive after taking Lulipan ?

Lulipan may occasionally cause dizziness which may affect your ability to drive or operate machinery.

How long does Lulipan take to work?

Lulipan is usually applied once a day for 1 week. To treat athlete's foot, Lulipan is usually applied once a day for 2 weeks.

Can I take Lulipan for a long time?

You usually take Lulipan for a short time to clear an infection. If you have a serious infection, you may need to take Lulipan long term. It is safe to take for a long time if your doctor has advised you to.

Who should not take Lulipan?

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

What happens if I overdose of Lulipan?

Seek emergency medical attention. Overdose symptoms may include confusion or unusual thoughts or behavior.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not use two doses at one time.

What happen If I stop taking Lulipan?

If you stop taking the drug suddenly or don't take it at all your infection may not get better or may get worse.

Can I take Lulipan every other day?

You'll usually take Lulipan once a day.

Can Lulipan damage the liver?

The severity of liver injury from Lulipan ranges from mild and transient enzyme elevations to clinically apparent hepatitis to acute liver failure and death.

Is Lulipan bad for kidneys?

Increased side effects can include kidney damage. Your doctor will check your blood for signs of kidney damage while you're taking Lulipan. If you show signs of kidney damage, your doctor may lower your doses of these drugs or stop them completely until your treatment with Lulipan is done.

Can Lulipan affect my fertility?

An experimental animal study did not find Lulipan to affect fertility.

*** Taking medicines without doctor's advice can cause long-term problems.