Lufyllin-400

Lufyllin-400 Uses, Dosage, Side Effects, Food Interaction and all others data.

Lufyllin-400 is a theophylline derivative with broncho- and vasodilator properties. It is typically used in the management of asthma, cardiac dyspnea, and bronchitis.

Lufyllin-400, a xanthine derivative, is a bronchodilator used for relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema. Lufyllin-400 is a xanthine derivative with pharmacologic actions similar to theophylline and other members of this class of drugs. Its primary action is that of bronchodilation, but it also exhibits peripheral vasodilatory and other smooth muscle relaxant activity to a lesser degree.

Trade Name Lufyllin-400
Availability Discontinued
Generic Dyphylline
Dyphylline Other Names Dihydroxypropyl theopylin, Diprofilina, Diprophylline, Diprophyllinum, Dyphylline
Related Drugs Trelegy Ellipta, amoxicillin, prednisone, doxycycline, ciprofloxacin, azithromycin, ceftriaxone, levofloxacin, Symbicort, Breo Ellipta
Type
Formula C10H14N4O4
Weight Average: 254.2426
Monoisotopic: 254.101504956
Protein binding

84%

Groups Approved
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Lufyllin-400
Lufyllin-400

Uses

Lufyllin-400 is a theophylline derivative used to treat asthma, bronchospasm, and COPD.

For relief of acute bronchial asthma and for reversible bronchospasm associated with chronic bronchitis and emphysema.

Lufyllin-400 is also used to associated treatment for these conditions: Bronchial Asthma, Bronchospasm, Cheyne-Stokes Respiration

How Lufyllin-400 works

The bronchodilatory action of dyphylline, as with other xanthines, is thought to be mediated through competitive inhibition of phosphodiesterase with a resulting increase in cyclic AMP producing relaxation of bronchial smooth muscle as well as antagonism of adenosine receptors.

Toxicity

LD50=1954 mg/kg (orally in mice)

Lufyllin-400 Hypertension interaction

[Moderate] Like other methylxanthines, dyphylline at high dosages may be associated with positive inotropic and chronotropic effects on the heart.

Therapy with dyphylline and products containing dyphylline should be administered cautiously in patients with severe cardiac disease, hypertension, hyperthyroidism, or recent myocardial infarction.

The relationship between plasma dyphylline levels and therapeutic as well as toxic effects has not been determined.

Lufyllin-400 Disease Interaction

Major: renal dysfunction, PUDModerate: cardiotoxicity, GERD

Half Life

2 hours (range 1.8 - 2.1 hours)

Elimination Route

Lufyllin-400 exerts its bronchodilatory effects directly and, unlike the­ophylline, is excreted unchanged by the kidneys without being metabolized by the liver. Approximately 88% of a single oral dose can be recovered from the urine unchanged.

Innovators Monograph

You find simplified version here Lufyllin-400

*** Taking medicines without doctor's advice can cause long-term problems.
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