Lomexin Vaginal

Lomexin Vaginal Uses, Dosage, Side Effects, Food Interaction and all others data.

Lomexin Vaginal is a potent broad-spectrum antimycotic agent. It exerts fungistatic and fungicidal actions on dermatophytes, pathogenic yeasts, dimorphous fungi and molds. In addition, Lomexin Vaginal is active against gram-positive bacteria and is therefore indicated in mycoses associated with bacterial super infections.

Lomexin Vaginal is also active, both in vitro and in vivo, against Trichomonas vaginalis.

Lomexin Vaginal exerts its unique antimycotic action through following three ways:

Inhibiting the biosynthesis of ergosterol leading to the damage of fungal cell membrane.Causing certain changes in oxidative and peroxidative enzyme activities inside fungal cell. This leads to an intracellular build-up of toxic concentrations of hydrogen peroxide resulting in cell necrosis.Inhibiting the secretion of aspartic proteases (responsible for pathogenicity) by Candidaalbicans.The amount of Lomexin Vaginal absorbed by the transcutaneous route is negligible.

Inhibitingthebiosynthesisofergosterolleadingtothedamageoffungalcellmembrane.Causingcertainchangesinoxidativeandperoxidativeenzymeactivitiesinsidefungalcell.Thisleadstoanintracellularbuild-upoftoxicconcentrationsofhydrogenperoxideresultingincellnecrosis.Inhibitingthesecretionofasparticproteases(responsibleforpathogenicity)byCandidaalbicans.TheamountofLomexin Vaginalabsorbedbythetranscutaneousrouteisnegligible.

Trade Name Lomexin Vaginal
Generic Fenticonazole
Fenticonazole Other Names Fenticonazole
Weight 2%w/w
Type Vag Cream
Formula C24H20Cl2N2OS
Weight Average: 455.4
Monoisotopic: 454.0673398
Groups Experimental
Therapeutic Class Topical Antifungal preparations
Manufacturer Pacific Pharmaceuticals Ltd,
Available Country Pakistan
Last Updated: September 19, 2023 at 7:00 am
Lomexin Vaginal
Lomexin Vaginal

Uses

Lomexin Vaginal Nitrate is used for:

  • Genital candidiasis (vulvovaginitis, colpitis, infectious fuor)
  • Trichomonasis
  • Vaginal infections sustained by mixed forms of Trichomonas vaginalis and Candida albicans.

Lomexin Vaginal is also used to associated treatment for these conditions: Balanitis, Balanoposthitis, Candidiasis of skin NOS, Dermatomycoses, Erythrasma, Genital candidiasis, Infection caused by Malassezia infection of the scalp, Mycoses, Nail infection, Onycholysis, Otomycosis, Pityriasis versicolor, Tinea Capitis, Tinea Corporis, Tinea Cruris, Tinea Pedis, Tinea Unguium, Tinea barbae, Tinea faciei, Tinea manuum, Trichophytosis, Vaginal Candidiasis

Dosage

Lomexin Vaginal dosage

ginal tablet-

  • Vaginal infections: Lomexin Vaginal 600 mg vaginal tablet(followed by a second administration 24 hours later, if necessary).
  • Candida albicans infections: Lomexin Vaginal 600 mg vaginal tablet administration in the evening. Should the symptoms persist, a second administration may be repeated after three days. The vaginal tablet must be introduced deep into the vagina and pushed well up to the fornix. To avoid re-infection, it is recommended that the partner undergoes concurrent treatment with Lomexin Vaginal Cream or similar Azole Cream.

Cream

  • : Apply 2% cream once daily

Side Effects

After intravaginal administration slight transient burning (which usually disappears rapidly) may occasionally happen. Prolonged topical application may cause sensitisation reactions. Lomexin Vaginal is generally well tolerated by the mucous membranes; only exceptionally mild and transient erythematous reactions have been reported. After topical application or intravaginal administration, a slight burning sensation may occur, usually subsiding soon. Should more persistent irritation occur or resistant micro-organism develop, suspend the treatment and seek the doctor's advice. Due to poor absorption of Lomexin Vaginal, no systemic efects should occur, provided the above instructions are carefully observed.

Precaution

Discontinue if sensitization or irritation occur. Pregnancy and lactation

Pregnancy & Breastfeeding use

It is not recommended in pregnancy. Safety in breastfeeding has not been established.

Contraindication

Contraindicated in case of hypersensitivity to Lomexin Vaginal and other Imidazoles.

Special Warning

Lomexin Vaginal Nitrate is not recommended for children.

Acute Overdose

As systemic absorption is very low, the possibility of overdose is rare. In case of accidental swallowing, emesis or gastric lavage should be done. After vomiting, active charcoal along with water/lemon juice and laxative should be given to the patient.

Storage Condition

Store below 25°C. Protect from light & moisture.

Innovators Monograph

You find simplified version here Lomexin Vaginal

*** Taking medicines without doctor's advice can cause long-term problems.
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