Levacetylmethadolum

Levacetylmethadolum Uses, Dosage, Side Effects, Food Interaction and all others data.

A narcotic analgesic with a long onset and duration of action. It is used mainly in the treatment of narcotic dependence.

Levomethadyl acetate (also known as LAAM) is a synthetic synthetic opioid analgesic with multiple actions quantitatively similar to those as morphine, the most prominent of which involve the central nervous system and organs composed of smooth muscle. However, levomethadyl acetate is more active and more toxic than morphine. The principal actions of therapeutic value are analgesia and sedation and detoxification or temporary maintenance in narcotic addiction. In this respect, the drug is similar to Methadone and also has structural similarities to it. The levomethadyl acetate abstinence syndrome, although qualitatively similar to that of morphine, differs in that the onset is slower, the course is more prolonged, and the symptoms are less severe.

Trade Name Levacetylmethadolum
Generic Levacetylmethadol
Levacetylmethadol Other Names 1-alpha-Acetylmethadol, LAAM, Levacetilmetadol, Levacetylmethadol, Levacetylmethadolum, Levo-alpha-acetylmethadol, Levo-methadyl acetate, Levomethadyl, Levomethadyl acetate
Type
Formula C23H31NO2
Weight Average: 353.4977
Monoisotopic: 353.235479241
Protein binding

Approximately 80%

Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Levacetylmethadolum
Levacetylmethadolum

Uses

For the treatment and management of opiate dependence. It is sometimes used to treat severe pain in terminal patients.

How Levacetylmethadolum works

Opiate receptors (Mu, Kappa, Delta) are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. Binding of the opiate stimulates the exchange of GTP for GDP on the G-protein complex. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. Opioids also inhibit the release of vasopressin, somatostatin, insulin and glucagon. Levomethadyl acetate effectively opens calcium-dependent inwardly rectifying potassium channels (OP1 receptor agonist), resulting in hyperpolarization and reduced neuronal excitability.

Toxicity

Signs of overdose include apnea, circulatory collapse, pulmonary edema, cardiac arrest, and death.

Elimination Route

Levomethadyl acetate is rapidly absorbed from an oral solution.

Half Life

2.6 days

Innovators Monograph

You find simplified version here Levacetylmethadolum

http://classyfire.wishartlab.com/tax_nodes/C0000000
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http://classyfire.wishartlab.com/tax_nodes/C0002279
http://classyfire.wishartlab.com/tax_nodes/C0000369
http://classyfire.wishartlab.com/tax_nodes/C0000369
http://classyfire.wishartlab.com/tax_nodes/C0003899
http://classyfire.wishartlab.com/tax_nodes/C0002239
http://classyfire.wishartlab.com/tax_nodes/C0001238
http://classyfire.wishartlab.com/tax_nodes/C0000347
http://classyfire.wishartlab.com/tax_nodes/C0001137
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0003940
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http://classyfire.wishartlab.com/tax_nodes/C0001831
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http://www.genome.jp/dbget-bin/www_bget?cpd:C08012
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=15130
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https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=237005
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https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL1514
https://zinc.docking.org/substances/ZINC000001530967
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP001139
http://www.pharmgkb.org/drug/PA450215
http://www.rxlist.com/cgi/generic2/levomethadyl.htm
https://www.drugs.com/cons/levomethadyl.html
https://en.wikipedia.org/wiki/Levacetylmethadol
*** Taking medicines without doctor's advice can cause long-term problems.
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