Лазонгин Uses, Dosage, Side Effects and more

Лазонгин is a metabolite of Bromhexine. It possesses mucokinetic (improvement in mucus transport) and secretolytic (liquefies secretions) properties. Лазонгин stimulates the serous cells of the glands of the mucous membrane of bronchi, increasing the content of mucus secretion. The mucolytic effect is associated with depolymerization and splitting of mucoproteins and mucopolysaccharide fibres, which leads to reduction in the viscosity of mucus. Expectoration of mucus is facilitated and breathing is eased considerably. Лазонгин stimulates production of phospholipids of surfactant by alveolar cells. Лазонгин has anti-inflammatory properties. In patients with COPD, it improves airway patency. Beside these, Лазонгин also exhibits anti-oxidant activity. Long-term use is possible because of the good tolerability of the preparation.

Attribute	Details
Trade Name	Лазонгин
Generic	Ambroxol
Ambroxol Other Names	Ambroxol, Ambroxolum, Bisolvon metabolite vIII, Bromhexine metabolite vIII, Bromhexine-metabolite vIII
Type
Formula	C13H18Br2N2O
Weight	Average: 378.108 Monoisotopic: 375.978589
Protein binding	Approximately 90%
Groups	Approved, Investigational
Therapeutic Class	Cough expectorants & mucolytics
Manufacturer
Available Country	Russia
Last Updated:	January 7, 2025 at 1:49 am

Uses

• • Acute and chronic diseases of respiratory tracts associated with viscid mucus including acute and chronic bronchitis
• • Productive cough
• • Inflammatory diseases of Rhinopharyngeal tract (e.g. Laryngitis, Pharyngitis, Sinusitis and Rhinitis) associated with viscid mucus
• • Asthmatic bronchitis, Bronchial asthma with difficult departure of mucus
• • Bronchiectasis
• • Chronic pneumonia.

Лазонгин is also used to associated treatment for these conditions: Airway secretion clearance therapy

How Лазонгин works

Лазонгин is a mucolytic agent. Excessive Nitric oxide (NO) is associated with inflammatory and some other disturbances of airways function. NO enhances the activation of soluble guanylate cyclase and cGMP accumulation. Лазонгин has been shown to inhibit the NO-dependent activation of soluble guanylate cyclase. It is also possible that the inhibition of NO-dependent activation of soluble guanylate cyclase can suppress the excessive mucus secretion, therefore it lowers the phlegm viscosity and improves the mucociliary transport of bronchial secretions.

Dosage

Average daily dose (preferably after meal):Pediatric Drops:

• 0-6 months: 0.5 ml 2 times a day
• 6-12 months: 1 ml 2 times a day
• 1-2 years: 1.25 ml 2 times a day

Syrup:

• 2-5 years: 2.5 ml (1/2 teaspoonful) 2-3 times a day
• 5-10 years: 5 ml (1 teaspoonful) 2-3 times a day
• 10 years and adults: 10 ml (2 teaspoonful) 3 times a day.

Sustained release capsule:

• Adult and children over 12 years old: 1 capsule once daily

Specific application features: Лазонгин may be prescribed to patients suffering from diabetes mellitus.

Side Effects

Gastrointestinal side-effects like epigastric pain, gastric fullness may occur occasionally. Rarely allergic responses such as eruption, urticaria or angioneurotic edema may occur.

Precaution

Лазонгин should be given cautiously to patients with gastric and duodenal ulceration or convulsive disorders. Patients with hepatic and renal insufficiency should take it with caution.

Interaction

Лазонгин has no interaction with cardioactive glycosides, corticosteroids, bronchodilators, diuretics and antibiotics (normally used in the treatment of bronchopulmonary affections). But Лазонгин should not be taken simultaneously with antitussives (e.g. Codeine) because mucus, which has been liquefied by Лазонгин, might not be expectorated.

Elimination Route

Rapid and almost complete.

Half Life

7-12 hours

Pregnancy & Breastfeeding use

Pregnancy: Teratogenic and fetal toxicity studies have shown no harmful effect of Лазонгин. However, it is advised not to use during pregnancy, especially in the 1st trimester.

Lactation: Safety during lactation has not been established.

Contraindication

Contraindicated in known hypersensitivity to Лазонгин or Bromhexine.

Interaction with other Medicine

Лазонгин has no interaction with cardioactive glycosides, corticosteroids, bronchodilators, diuretics and antibiotics (normally used in the treatment of bronchopulmonary affections). But Лазонгин should not be taken simultaneously with antitussives (e.g. Codeine) because mucus, which has been liquefied by Лазонгин, might not be expectorated.

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