KL4-surfactant
KL4-surfactant Uses, Dosage, Side Effects, Food Interaction and all others data.
KL4-surfactant is a new synthetic peptide-containing surfactant for intratracheal use. It contains sinapultide, a novel, hydrophobic, 21-amino acid peptide (leucine and lysine repeating units, KL4 peptide) designed to mimic human surfactant protein-B (SB-P). More specifically, it mimics the C-terminal amphipathic helical domain of this protein. It also consists of phospholipids (dipalmitoylphosphatidylcholine, DPPC and palmitoyloleoyl phosphatidylglycerol, POPG) and a fatty acid (palmitic acid). It is completely devoid of animal-derived components. FDA approved on March 6, 2012.
KL4-surfactant is a new synthetic surfactant containing a protein that mimics human surfactant protein-B, is effective at preventing respiratory distress syndrome (RDS) and related complications in preterm infants. KL4-surfactant has been shown to have antiinflammatory properties, is resistant to proteolytic degradation and oxidation, and has no potential for transmitting animal-derived diseases. KL4-surfactant has proven safe and effective in the prevention of RDS in preterm infants and as a treatment for MAS in full-term infants and for adult ARDS.
| Trade Name | KL4-surfactant |
| Availability | Discontinued |
| Generic | Lucinactant |
| Lucinactant Other Names | ATI-02, KL4-surfactant, Lucinactant |
| Related Drugs | beractant, calfactant, Curosurf, Survanta, Infasurf, Surfaxin |
| Type | |
| Formula | C 126 H 238 N 26 O 22 |
| Weight | 2470.2 Da |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Intended for the prevention of respiratory distress syndrome (RDS) in premature infants at high risk for RDS.
How KL4-surfactant works
Pulmonary surfactant is a lipoprotein complex that is produced naturally in the lungs, where it lines the alveolar epithelium and serves to reduce surface tension, which facilitates alveoli expansion and allows gas exchange. Human surfactants contain phospholipids, predominantly dipalmitoylphosphatidylcholine (DPPC), in addition to surfactant proteins A, B, C and D. Surfactant is also a physical barrier to inhaled particle and noxious agents, enhances particle clearance, is involved in host defense against infection and possesses antiinflammatory properties. Several serious respiratory disorders have been associated with a loss or lack of endogenous surfactant. KL4-surfactant was designed to mimic the essential endogenous human surfactant protein B (SP-B).
Toxicity
Most common adverse reactions associated with the use of lucinactant are endotracheal tube reflux, pallor, endotracheal tube obstruction, and need for dose interruption.
Innovators Monograph
You find simplified version here KL4-surfactant
