Jaa Prednisone

Jaa Prednisone Uses, Dosage, Side Effects, Food Interaction and all others data.

A synthetic anti-inflammatory glucocorticoid derived from cortisone. It is biologically inert and converted to prednisolone in the liver.

Jaa Prednisone was granted FDA approval on 21 February 1955.

Corticosteroids bind to the glucocorticoid receptor, inhibiting pro-inflammatory signals, and promoting anti-inflammatory signals. Jaa Prednisone has a short duration of action as the half life is 2-3 hours. Corticosteroids have a wide therapeutic window as patients make require doses that are multiples of what the body naturally produces. Patients taking corticosteroids should be counselled regarding the risk of hypothalamic-pituitary-adrenal axis suppression and increased susceptibility to infections.

Trade Name Jaa Prednisone
Availability Prescription only
Generic Prednisone
Prednisone Other Names 1,2-Dehydrocortisone, Dehydrocortisone, Prednisona, Prednisone, Prednisonum
Related Drugs Humira, Cosentyx, Dupixent, Gilenya, Promacta, Tysabri, Benlysta, Trelegy Ellipta, Vumerity, aspirin
Formula C21H26O5
Weight Average: 358.4281
Monoisotopic: 358.178023942
Protein binding

Corticosteroids are generally bound to corticosteroid binding globulin and serum albumin in plasma. Prednisone is 3

Groups Approved, Vet approved
Therapeutic Class
Available Country Canada, United States
Last Updated: September 19, 2023 at 7:00 am
Jaa Prednisone
Jaa Prednisone


Jaa Prednisone is a corticosteroid used to treat inflammation or immune-mediated reactions and to treat endocrine or neoplastic diseases.

Jaa Prednisone is indicated as an anti-inflammatory or immunosuppressive drug for allergic, dermatologic, gastrointestinal, hematologic, ophthalmologic, nervous system, renal, respiratory, rheumatologic, infectious, endocrine, or neoplastic conditions as well as in organ transplant.

Jaa Prednisone is also used to associated treatment for these conditions: Acne Vulgaris, Acute Gouty Arthritis, Acute Lymphoblastic Leukaemias (ALL), Aggressive Lymphoma, Allergic Bronchopulmonary Aspergillosis, Allergic Rhinitis (AR), Allergic corneal marginal ulcers, Alveolitis, Extrinsic Allergic, Ankylosing Spondylitis (AS), Anterior Segment Inflammation, Aspiration Pneumonitis, Asthma, Atopic Dermatitis (AD), Bell's Palsy, Berylliosis, Bullous dermatitis herpetiformis, Chorioretinitis, Chronic Obstructive Airways Disease Exacerbated, Congenital Adrenal Hyperplasia (CAH), Congenital Hypoplastic Anemia, Corneal Inflammation, Crohn's Disease (CD), Dermatitis exfoliative generalised, Dermatitis, Contact, Dermatomyositis, Disseminated tuberculosis, Drug hypersensitivity reaction, Edema of the cerebrum, Epicondylitis, Erythroblastopenia, Giant Cell Arteritis (GCA), Hepatitis, Autoimmune, Hypercalcemia of Malignancy, Idiopathic Thrombocytopenic Purpura, Iridocyclitis, Iritis, Leukemia, Acute, Leukemias, Loeffler's syndrome, Malignant Lymphomas, Metastatic Castration Resistant Prostate Cancer, Multiple sclerosis exacerbation, Mycosis Fungoides (MF), Ocular Inflammation, Ophthalmia, Sympathetic, Optic Neuritis, Pain caused by Herpes zoster, Pemphigus, Pericarditis, Pneumocystis Jirovecii Pneumonia, Polymyalgia Rheumatica, Primary adrenocortical insufficiency, Proteinuria, Psoriatic Arthritis, Pulmonary Fibrosis, Pure Red Cell Aplasia, Relapsing Polychondritis, Rheumatic heart disease, unspecified, Rheumatoid Arthritis, Rheumatoid Arthritis, Juvenile, Seasonal Allergic Conjunctivitis, Secondary adrenocortical insufficiency, Secondary thrombocytopenia, Serum Sickness, Severe Seborrheic Dermatitis, Sjögren's Syndrome, Stevens-Johnson Syndrome, Systemic Lupus Erythematosus (SLE), Takayasu's Disease, Thyroid Eye Disease, Thyroiditis, Thyrotoxicosis, Trichinosis, Tuberculous Meningitis, Ulcerative Colitis, Uveitis, Vasculitis, Acquired immune hemolytic anemia, Acute Bursitis, Acute Tenosynovitis, Bronchiolitis obliterans organizing pneumonia, Fulminating Tuberculosis, Idiopathic eosinophilic pneumonias, Non-suppurative Thyroiditis, Severe Psoriasis, Solid organ rejection, Subacute Bursitis, Symptomatic Sarcoidosis, Synovitis of osteoarthritis, Systemic Dermatomyositis, Varicella-zoster virus acute retinal necrosis

How Jaa Prednisone works

Jaa Prednisone is first metabolized in the liver to its active form, prednisolone, a glucocorticoid agonist corticosteroid.

The short term effects of corticosteroids are decreased vasodilation and permeability of capillaries, as well as decreased leukocyte migration to sites of inflammation. Corticosteroids binding to the glucocorticoid receptor mediates changes in gene expression that lead to multiple downstream effects over hours to days.

Glucocorticoids inhibit neutrophil apoptosis and demargination; they inhibit phospholipase A2, which decreases the formation of arachidonic acid derivatives; they inhibit NF-Kappa B and other inflammatory transcription factors; they promote anti-inflammatory genes like interleukin-10.

Lower doses of corticosteroids provide an anti-inflammatory effect, while higher doses are immunosuppressive. High doses of glucocorticoids for an extended period bind to the mineralocorticoid receptor, raising sodium levels and decreasing potassium levels.


Data regarding acute overdoses of prednisone are rare but prolonged high doses of prednisone can lead to a higher incidence and severity of adverse effects such as mental symptoms, moon face, abnormal fat deposits, fluid retention, excessive appetite, weight gain, hypertrichosis, acne, striae, ecchymosis, increased sweating, pigmentation, dry scaly skin, thinning scalp hair, increased blood pressure, tachycardia, thrombophlebitis, decreased resistance to infection, negative nitrogen balance with delayed bone and wound healing, headache, weakness, menstrual disorders, accentuated menopausal symptoms, neuropathy, fractures, osteoporosis, peptic ulcer, decreased glucose tolerance, hypokalemia, and adrenal insufficiency.

Food Interaction

  • Avoid alcohol.
  • Take with food. Food reduces irritation.

Jaa Prednisone Cholesterol interaction

[Moderate] Corticosteroids may elevate serum triglyceride and LDL cholesterol levels if used for longer than brief periods.

Patients with preexisting hyperlipidemia may require closer monitoring during prolonged corticosteroid therapy, and adjustments made accordingly in their lipid-lowering regimen.

Jaa Prednisone Hypertension interaction

[Moderate] Corticosteroids may cause hypernatremia, hypokalemia, fluid retention, and elevation in blood pressure.

These mineralocorticoid effects are most significant with fludrocortisone, followed by hydrocortisone and cortisone, then by prednisone and prednisolone.

The remaining corticosteroids, betamethasone, dexamethasone, methylprednisolone, and triamcinolone, have little mineralocorticoid activities.

However, large doses of any corticosteroid can demonstrate these effects, particularly if given for longer than brief periods.

Therapy with corticosteroids should be administered cautiously in patients with preexisting fluid retention, hypertension, congestive heart failure, and

Dietary sodium restriction and potassium supplementation may be advisable.

Volume of Distribution

Data regarding the volume of distribution for prednisone is not readily available. However, a 0.15mg/kg dose of prednisolone has a volume of distribution of 29.3L, while a 0.30mg/kg dose has a volume of distribution of 44.2L.

Elimination Route

Oral prednisone has a Tmax of 2 hours, while the delayed-release formulation has a Tmax of 6-6.5 hours. A 5mg dose of prednisone has an AUC of 572mL/min/1.73m2 Data regarding the Cmax of prednisone is not readily available.

Half Life

Jaa Prednisone and its active metabolite prednisolone have half lives of 2-3 hours from both immediate and delayed release preparations.


Data regarding the clearance of prednisone is not readily available.

A 5.5µg/h/kg infusion of prednisolone has an average clearance of 0.066±0.12L/h/kg, while a 0.15±0.03L/h/kg infusion has an average clearance of 0.15L/h/kg.

Elimination Route

Jaa Prednisone is excreted mainly in the urine as sulfate and glucuronide conjugates.

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