Isopropyl Tetradecanoate

Isopropyl Tetradecanoate Uses, Dosage, Side Effects, Food Interaction and all others data.

Isopropyl Tetradecanoate is a moisturizer with polar characteristics used in cosmetics and topical medical preparations to ameliorate the skin absorption. Isopropyl Tetradecanoate has been largely studied and impulsed as a skin penetration enhancer.

At the moment the primary usage for which isopropyl myristate is formally indicated is as the active ingredient in a non-prescription pediculicide rinse .

Isopropyl Tetradecanoate is an emollient vehicle that is effective at enhancing the penetration of other medical agents that may be incorporated into the vehicle as active agents . In one study, a 50:50 isopropanol-isopropyl myristate binary enhancer synergistically increased the transport of estradiol across a two-layer human epidermis in vitro .

Trade Name Isopropyl Tetradecanoate
Generic Isopropyl myristate
Isopropyl myristate Other Names Isopropyl myristate, Isopropyl tetradecanoate
Type
Formula C17H34O2
Weight Average: 270.4507
Monoisotopic: 270.255880332
Protein binding

Readily available information regarding the pharmacokinetics of isopropyl myristate is not available .

Groups Approved, Experimental
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Isopropyl Tetradecanoate
Isopropyl Tetradecanoate

Uses

Isopropyl Tetradecanoate is a polar skin moisturizer that is used to enhance skin penetration of drugs.

The primary medical indication for which isopropyl myristate is formally used as an active ingredient in a patient care product is as a non-prescription pediculicide rinse .

Isopropyl Tetradecanoate is also used to associated treatment for these conditions: Head Lice Infestation

How Isopropyl Tetradecanoate works

As a pediculicide, isopropyl myristate is capable of physically coating the exoskeleton bodies of lice . This physical coating subsequently immobilizes the lice and works to dissolve the wax covering on the insect exoskeleton and blocks the insects' airways, leading to death by dehydration . Although this physical action of isopropyl myristate results in little lice resistance (given the lack of immunologic or chemical activity in this mechanism of action), the substance is also not ovicidal, which means any eggs that may have been laid by lice would not be affected . Moreover, isopropyl myristate is capable of eliciting its pediculicide action in a contact time of only 10 minutes per each necessary administration .

Toxicity

Readily available information regarding the pharmacokinetics of isopropyl myristate is not available .

Food Interaction

No interactions found.

Volume of Distribution

Readily available information regarding the pharmacokinetics of isopropyl myristate is not available .

Elimination Route

Dermal absorption of isopropyl myristate is predicated to be 0.00020 mg/cm2/event, which is considered a very low absorption rate . In a study, topically applied isopropyl myristate was largely retained in the stratum corneum . It was not detected in the receptor fluid of flow-through diffusion cells in in-vitro skin permeation experiments using human epidermis (stratum corneum and viable epidermis) and dermis of varying thickness .

Half Life

Readily available information regarding the pharmacokinetics of isopropyl myristate is not available .

Clearance

Readily available information regarding the pharmacokinetics of isopropyl myristate is not available .

Elimination Route

Readily available information regarding the pharmacokinetics of isopropyl myristate is not available .

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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