Isopropyl Phosphorofluoridate

Isopropyl Phosphorofluoridate Uses, Dosage, Side Effects, Food Interaction and all others data.

An irreversible cholinesterase inhibitor with actions similar to those of echothiophate. It is a powerful miotic used mainly in the treatment of glaucoma. Its vapor is highly toxic and it is recommended that only solutions in arachis oil be used therapeutically. (From Martindale, The Extra Pharmacopoeia, 29th ed, p1330)

Isopropyl Phosphorofluoridate is used as ocular drops in the treatment of chronic glaucoma. Isopropyl Phosphorofluoridate is an organophosphorus compound that acts as an irreversible cholinesterase inhibitor. As such, it displays parasympathomimetic effects. Isopropyl Phosphorofluoridate is used in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia. They may also be used in the diagnosis of certain eye conditions, such as accommodative esotropia. Isopropyl Phosphorofluoridate damages the acetylcholinesterase enzyme and is therefore irreversible, however, pralidoxime can displace organophosphates such as isoflurophate from acetylcholinesterase, but only if administered before isoflurophate damages (alkylates) the enzyme.

Trade Name Isopropyl Phosphorofluoridate
Generic Isoflurophate
Isoflurophate Other Names Diisopropoxyphosphoryl fluoride, Diisopropyl fluorophosphate, Diisopropyl fluorophosphonate, Diisopropyl phosphofluoridate, Diisopropyl phosphorofluoridate, Diisopropylfluorophosphate, Diisopropylfluorophosphoric acid ester, Diisopropylphosphofluoridate, Diisopropylphosphorofluoridate, Fluorodiisopropyl phosphate, Fluorostigmine, Isofluorphate, Isoflurophate, Isoflurophosphate, Isopropyl fluophosphate, Isopropyl phosphorofluoridate
Type
Formula C6H14FO3P
Weight Average: 184.1457
Monoisotopic: 184.066459031
Groups Approved, Investigational, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Isopropyl Phosphorofluoridate
Isopropyl Phosphorofluoridate

Uses

For use in the eye to treat certain types of glaucoma and other eye conditions, such as accommodative esotropia.

How Isopropyl Phosphorofluoridate works

The mechanism of isoflurophate's action involves the irreversible inhibition of cholinesterase.

Toxicity

Signs of overdose include increased sweating, loss of bladder control, muscle weakness, nausea, vomiting, diarrhea, or stomach cramps or pain, shortness of breath, tightness in chest, or wheezing, slow or irregular heartbeat, unusual tiredness or weakness, watering of mouth.

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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