Interferon Gamma-2a

Interferon Gamma-2a Uses, Dosage, Side Effects, Food Interaction and all others data.

Human Interferon Gamma-2a (140 residues), produced from E. coli. Production of Actimmune is achieved by fermentation of a genetically engineered Escherichia coli bacterium containing the DNA which encodes for the human protein. Purification of the product is achieved by conventional column chromatography.The sequence displayed is a cDNA sequence which codes for human interferon gamma, as described by Gray et. al. and not specifically interferon gamma 1b.

IFN gamma stimulates expression of the immunoglobulin heavy chain C gamma 3 and C gamma 2a germline transcripts in B cells. Many components of the antigen presentation pathways are also up-regulated by interferon gamma. It is also a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of type I interferons. Interferon gamma may also help the body regulate the activity of fibroblasts. By directly blocking the multiplication of fibroblasts and inhibiting the production and action of TGF-b, a potent scar-inducing molecule, Interferon Gamma-2a may prevent excessive scarring.

Trade Name Interferon Gamma-2a
Generic Interferon gamma-1b
Interferon gamma-1b Other Names IFN-gamma 1b, IFN-gamma-1b, Interferon gamma 1-b, Interferon gamma-1b, Interferon gamma-1b, recombinant, Interferon gamma-2a
Type
Formula C761H1206N214O225S6
Weight 17145.6 Da
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Interferon Gamma-2a
Interferon Gamma-2a

Uses

Interferon Gamma-2a is a form of recombinant human interferon used to treat infections associated with chronic granulomatous disease and to slow the progression of severe malignant osteopetrosis.

Interferon Gamma-2a is used for the treatment of Chronic granulomatous disease and Osteopetrosis.

Interferon Gamma-2a is also used to associated treatment for these conditions: Chronic Granulomatous Disease (CGD), Severe, malignant Osteopetrosis

How Interferon Gamma-2a works

Binds directly to the type II interferon gamma receptor IFNGR1, leading to a complex of IFNGR1 and IFNGR2. This activates JAK1 and JAK2 kinases which form a STAT1 docking site. This leads to STAT1 phosphorylation, nuclear translocation and initiation of gene transcription of multiple immune-related genes.

Food Interaction

  • Avoid excessive or chronic alcohol consumption. Interferon Gamma-2a may cause fatigue, drowsiness, and confusion. These effects may be exacerbated by alcohol consumption.

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*** Taking medicines without doctor's advice can cause long-term problems.
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