Indium (111In) Satumomab Pendetide

Indium (111In) Satumomab Pendetide Uses, Dosage, Side Effects, Food Interaction and all others data.

Tumor associated glycoprotein (TAG) 72 (B72.3) monoclonal antibody conjugated with Indium 111 for radioimaging colon tumors. Satumomab Pendetide (trade name: OncoScint®) is no longer commercially available.

Binds to the tumor associated glycoprotein 72 antigen, which is a cell surface protein generally over-expressed in colorectal cancers. The radioactive Indium 111, which is covalently attached to the antibody, allows radiodiagnostic detection of TAG-72 expressing cells and tumors.

Trade Name Indium (111In) Satumomab Pendetide
Generic Indium In-111 satumomab pendetide
Indium In-111 satumomab pendetide Other Names Indium (111In) satumomab pendetide, Indium In 111 satumomab pendetide, Indium-111 satumomab pendetide
Type
Formula C6268H9708N1666O1971S48
Weight 141478.9 Da
Groups Experimental, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Indium (111In) Satumomab Pendetide
Indium (111In) Satumomab Pendetide

Uses

For diagnosis of extrahepatic malignant cancers

How Indium (111In) Satumomab Pendetide works

Satumomab Pendetide is a monoclonal antibody which is attached to the chelator pentetic acid (DTPA) linked to the tripeptide glycine (G) – L-tyrosine (Y) – L-lysine (K), which chelates Indium 111. Satumomab pendetide binds selectively to cell-surface TAG-72 expressed on colorectal tumors.

Half Life

0.8 hours (mammalian reticulocytes, in vitro)

Innovators Monograph

You find simplified version here Indium (111In) Satumomab Pendetide

*** Taking medicines without doctor's advice can cause long-term problems.
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