Inamrinone Uses, Dosage, Side Effects and more
Inamrinone (or inamrinone) is a type 3 pyridine phosphodiesterase inhibitor. It is used in the treatment of congestive heart failure.
Inamrinone is a positive inotropic cardiotonic with vasodilator properties, phosphodiesterase inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell.
| Attribute | Details |
|---|---|
| Trade Name | Inamrinone |
| Generic | Amrinone |
| Amrinone Other Names | Amrinona, Amrinone, Amrinonum, Inamrinone |
| Type | |
| Formula | C10H9N3O |
| Weight | Average: 187.198 Monoisotopic: 187.074561925 |
| Protein binding | 10 to 49% |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Inamrinone is a positive inotropic agent and phosphodiesterase inhibitor used in the management of treatment of congestive heart failure.
Used in the treatment of congestive heart failure.
How Inamrinone works
Inamrinone is a phosphodiesterase inhibitor (PDE3), resulting in increased cAMP and cGMP which leads to an increase in the calcium influx like that caused by beta-agonists resulting in increased inotropic effect.
Volume of Distribution
- 1.2 L/kg [normal volunteers]
Half Life
5 to 8 hours
Elimination Route
The primary route of excretion in man is via the urine as both inamrinone and several metabolites (N-glycolyl, N-acetate, O-glucuronide and N-glucuronide).
