Heminevrin / Clomethiazole Uses, Dosage, Side Effects and more
Heminevrin / Clomethiazole is a well-established γ-aminobutyric acid (GABAA)-mimetic drug. It is a sedative and hypnotic that is widely used in treating and preventing symptoms of acute alcohol withdrawal. It is a drug which is structurally related to thiamine (vitamin B1) but acts like a sedative, hypnotic, muscle relaxant and anticonvulsant. It is also used for the management of agitation, restlessness, short-term insomnia and Parkinson's disease in the elderly.
| Attribute | Details |
|---|---|
| Trade Name | Heminevrin / Clomethiazole |
| Generic | Clomethiazole |
| Clomethiazole Other Names | Clomethiazole, Clomethiazolum, Clometiazol |
| Type | Capsule |
| Formula | C6H8ClNS |
| Weight | Average: 161.65 Monoisotopic: 161.0065981 |
| Groups | Investigational |
| Therapeutic Class | |
| Manufacturer | Cheplapharm Arzneimittel GmbH |
| Available Country | United Kingdom |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Investigated for use/treatment in strokes.
How Heminevrin / Clomethiazole works
clomethiazole interacts with the GABAA receptor complex. It inhibits the binding of [35S]butyl-bicyclophosphorothionate (TBPS), an effect indicative of GABAA receptor-channel activation, by increasing the rate of [35S]TBPS dissociation and decreasing the binding affinity. Gamma-aminobutyric acid (GABA), acting at GABAA receptors, is the main fast inhibitory neurotransmitter in mammalian central nervous system
