Gubernal

Gubernal Uses, Dosage, Side Effects, Food Interaction and all others data.

One of the adrenergic beta-antagonists used as an antihypertensive, anti-anginal, and anti-arrhythmic agent. Gubernal is no longer marketed by AstraZeneca, but may still be available in generic varieties.

Gubernal is a non-selective beta-blocker used in the treatment of hypertension, edema, ventricular tachycardias, and atrial fibrillation. Gubernal impairs AV node conduction and decreases sinus rate and may also increase plasma triglycerides and decrease HDL-cholesterol levels. Gubernal is nonpolar and hydrophobic, with low to moderate lipid solubility. Gubernal has little to no intrinsic sympathomimetic activity and, unlike some other beta-adrenergic blocking agents, alprenolol has little direct myocardial depressant activity and does not have an anesthetic-like membrane-stabilizing action.

Trade Name Gubernal
Generic Alprenolol
Alprenolol Other Names Alfeprol, Alprenolol, Alprénolol, Alprenololum, Aprenololo
Type
Formula C15H23NO2
Weight Average: 249.3486
Monoisotopic: 249.172878985
Protein binding

80-90%

Groups Experimental, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Gubernal
Gubernal

Uses

For the treatment of hypertension, angina, and arrhythmia

How Gubernal works

Gubernal non-selectively blocks beta-1 adrenergic receptors mainly in the heart, inhibiting the effects of epinephrine and norepinephrine resulting in a decrease in heart rate and blood pressure. Also, with a more minor effect, by binding beta-2 receptors in the juxtaglomerular apparatus, alprenolol inhibits the production of renin, thereby inhibiting angiotensin II and aldosterone production and therefore inhibits the vasoconstriction and water retention due to angiotensin II and aldosterone, respectively.

Toxicity

LD50=597.0 mg/kg (Orally in rats)

Half Life

2-3 hours

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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