Guanidine Uses, Dosage, Side Effects, Food Interaction and all others data.

A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.

Guanidine apparently acts by enhancing the release of acetylcholine following a nerve impulse. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes.

Trade Name Guanidine
Availability Prescription only
Generic Guanidine
Guanidine Other Names Aminomethanamidine, Guanidin, Guanidine, Imidourea, Iminourea
Weight 125mg
Type Oral tablet
Formula CH5N3
Weight Average: 59.0705
Monoisotopic: 59.048347175
Groups Approved
Therapeutic Class
Available Country United States
Last Updated: September 19, 2023 at 7:00 am


Guanidine is a strong organic base used to treat muscle weakness and fatigue associated with the myasthenic complications of Eaton-Lambert syndrome.

For the reduction of the symptoms of muscle weakness and easy fatigability associated with the myasthenic syndrome of Eaton-Lambert. It is not indicated for treating myasthenia gravis.

Guanidine is also used to associated treatment for these conditions: Muscle Weakness


LD50 = 475 mg/kg (oral, rat). Can cause severe gastrointestinal symptoms (nausea, vomiting and diarrhea), bone marrow suppression, renal insufficiency and other hematologic abnormalities (anemia, leucopenia). Severe guanidine intoxication is characterized by nervous hyperirritability, fibrillary tremors and convulsive contractions of muscle, salivation, vomiting, diarrhea, hypoglycemia, and circulatory disturbances.

Food Interaction

No interactions found.

Elimination Route

Rapidly absorbed and distributed

Half Life

7-8 hours

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