Gonadotropin-releasing Hormone

Gonadotropin-releasing Hormone Uses, Dosage, Side Effects, Food Interaction and all others data.

Gonadotropin-releasing Hormone is another name for gonadotropin-releasing hormone (GnRH). It is a synthetic decapeptide prepared using solid phase peptide synthesis. GnRH is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pituitary.

Gonadotropin-releasing Hormone is responsible for the release of follicle stimulating hormone and leutinizing hormone from the anterior pitutitary. In the pituitary GnRH stimulates synthesis and release of FSH and LH, a process that is controlled by the frequency and amplitude of GnRH pulses, as well as the feedback of androgens and estrogens. The pulsatility of GnRH secretion has been seen in all vertebrates, and it is necessary to ensure a correct reproductive function. Thus a single hormone, GnRH, controls a complex process of follicular growth, ovulation, and corpus luteum maintenance in the female, and spermatogenesis in the male. Its short half life requires infusion pumps for its clinical use

Gonadotropin-releasing Hormone
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Uses during Pregnancy
Uses during Breastfeeding
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Trade Name	Gonadotropin-releasing Hormone
Availability	Discontinued
Generic	Gonadorelin
Gonadorelin Other Names	GnRH, Gonadorelin, Gonadorelina, Gonadoréline, Gonadorelinum, Gonadotropin-releasing hormone
Related Drugs	progesterone, norethindrone, medroxyprogesterone, Provera, Prometrium, Aygestin
Type
Formula	C₅₅H₇₅N₁₇O₁₃
Weight	Average: 1182.2901 Monoisotopic: 1181.573025571
Groups	Approved, Investigational, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Gonadotropin-releasing Hormone is a synthetic GnRH used to test the function of gonadotropes and the pituitary.

For evaluating the functional capacity and response of the gonadotropes of the anterior pituitary also for evaluating residual gonadotropic function of the pituitary following removal of a pituitary tumor by surgery and/or irradiation.

Gonadotropin-releasing Hormone is also used to associated treatment for these conditions: Ovulation induction therapy

How Gonadotropin-releasing Hormone works

Systemic - Like naturally occurring gonadotropin-releasing hormone (GnRH), gonadorelin primarily stimulates the synthesis and release of luteinizing hormone (LH) from the anterior pituitary gland. Follicle-stimulating hormone (FSH) production and release is also increased by gonadorelin, but to a lesser degree. In prepubertal females and some gonadal function disorders, the FSH response may be greater than the LH response. For the treatment of amenorrhea, delayed puberty, and infertility the administration of gonadorelin is used to simulate the physiologic release of GnRH from the hypothalamus in treatment of delayed puberty, treatment of infertility caused by hypogonadotropic hypogonadism, and induction of ovulation in those women with hypothalamic amenorrhea. This results in increased levels of pituitary gonadotropins LH and FSH, which subsequently stimulate the gonads to produce reproductive steroids.