Glypressin & Solvent for

Glypressin & Solvent for Uses, Dosage, Side Effects, Food Interaction and all others data.

Trade Name Glypressin & Solvent for
Generic Terlipressin
Terlipressin Other Names Terlipresina, Terlipressin, Terlipressina, Terlipressine, Terlipressinum
Type Injection
Formula C52H74N16O15S2
Weight Average: 1227.372
Monoisotopic: 1226.496097158
Protein binding

Approximately 30%

Groups Approved, Investigational
Therapeutic Class Other preparations
Manufacturer Ferring Pharmaceuticals Ltd
Available Country United Kingdom
Last Updated: September 19, 2023 at 7:00 am
Glypressin & Solvent for
Glypressin & Solvent for


For use in the short term management of bleeding oesophageal varices. "Emergency treatment of type 1 hepatorenal syndrome, as defined by IAC (International Ascites Club) criteria".
Elderly patients: There is no data available regarding dosage recommendation in the elderly.

Paediatric population: There is no data available regarding dosage recommendation in the paediatric population.

Glypressin & Solvent for is also used to associated treatment for these conditions: Hepatorenal Syndrome Type 1, Hepatorenal Syndrome Type I, Oesophageal varices haemorrhage, Portal Hypertension, Type 1 Hepatorenal Syndrome

How Glypressin & Solvent for works

Glypressin & Solvent for, an analogue of vasopressin, acts on three different receptors, vasopressin receptor V1a (which initiates vasoconstriction, liver gluconeogenesis, platelet aggregation and release of factor VIII), vasopressin receptor V1b (which mediates corticotrophin secretion from the pituitary) and vasopressin receptor V2 which controls free water reabsorption in the renal medullar. The binding of terlipressin to the V2 receptor activates adenylate cyclase which causes the release of aquaporin 2 channels into the cells lining the renal medullar duct. This allows water to be reabsorbed down an osmotic gradient so the urine is more concentrated.


Glypressin & Solvent for dosage

Short term management of bleeding oesophageal varices: Initially an i.v. injection of 2 mg (2x8.5 ml) terlipressin acetate is given every 4 hours. The treatment should be maintained until bleeding has been controlled for 24 hours, but up to a maximum of 48 hours. After the initial dose, the dose can be adjusted to 1 mg (8.5 ml) terlipressin acetate i.v. every 4 hours in patients with body weight <50 kg or if adverse effects

In type 1 hepatorenal syndrome: An i.v. injection 3 to 4 mg (3x8.5ml to 4x8.5ml) terlipressin acetate every 24 hours as 3 or 4 administrations. In the absence of any reduction of the serum creatinine after 3 days of treatment, cessation of Glypressin & Solvent for Acetate treatment is advised. In other cases, Glypressin & Solvent for Acetate treatment is to be pursued until the obtaining either of a serum creatinine less than 130 µmol/litre or of a drop of at least 30% in the serum creatinine with respect to the value measured at the time of diagnosis of hepatorenal syndrome. The standard average duration of treatment is 10 days.

Side Effects

The most frequently reported undesired effects in clinical trials are paleness, increased blood pressure, abdominal pain, nausea, diarrhoea, and headache.


Cardiac, pulmonary and vascular disease: During treatment regular monitoring and control of blood pressure, ECG, heart rate, serum levels of sodium and potassium, as well as fluid balance are required. Caution should be exercised in treating patients with hypertension, recognised heart disease, renal dysfunction, cerebral or peripheral vascular disease, asthma or respiratory failure.

Septic shock: In patients with septic shock with a low cardiac output terlipressin should not be used.

Injection site reaction: To avoid local necrosis at the injection site, the injection must be administered intravenously.

Torsade de pointes: During clinical trials and post-marketing experience, several cases of QT interval prolongation and ventricular arrhythmias including “Torsade de pointes” have been reported. In most cases, patients had predisposing factors such as basal prolongation of the QT interval, electrolyte abnormalities (hypokalemia, hypomagnesemia) or medications with concomitant effect on QT prolongation. Therefore, extreme caution should be exercised in the use of terlipressin in patients with a history of QT interval prolongation, electrolyte abnormalities, or concomitant medications that can prolong the QT interval.

Prior to use of terlipressin for hepatorenal syndrome, it must be ascertained that the patient has an acute functional renal failure and this functional renal failure does not respond to a suitable plasma expansion therapy.

Paediatric population and elderly patients: Particular caution should be exercised in the treatment of children and elderly patients, as experience is limited in these groups. There is no data available regarding dosage recommendation in these special patient categories.

Excipients: This medicinal product contains 1.33 mmol (30.7 mg) of sodium per ampoule, equivalent to 1.5% of the WHO recommended maximum daily intake of 2 g sodium for an adult.


The hypotensive effect of non-selective beta-blockers on the portal vein is increased with terlipressin. Concomitant treatment with medicinal products with a known bradycardiac effect (e.g. propofol, sufentanil) may lower the heart rate and cardiac output. These effects are due to reflexofenic inhibition of the cardiac activity via the vagus nerve due to elevated blood pressure. Glypressin & Solvent for can trigger "torsade de pointes". Therefore, extreme caution should be exercised in the use of terlipressin in patients with concomitant medications that can prolong the QT interval, such as class IA and III antiarrhythmics, erythromycin, certain antihistamines and tricyclic antidepressants or medications that may cause hypokalaemia or hypomagnesemia (e.g. some diuretics).

Pregnancy & Breastfeeding use

Treatment with Glypressin & Solvent for Acetate during pregnancy is contraindicated. Glypressin & Solvent for Acetate has been shown to cause uterine contractions and increased intrauterine pressure in early pregnancy and may decrease the uterine blood flow. Glypressin & Solvent for Acetate may have harmful effects on pregnancy and foetus. Spontaneous abortion and malformation of the foetus have been shown in rabbits after treatment with Glypressin & Solvent for Acetate.

It is not known whether Glypressin & Solvent for Acetate is excreted in human breast milk. The excretion of Glypressin & Solvent for Acetate in milk has not been studied in animals. A risk to the suckling child cannot be excluded. A decision on whether to continue/discontinue breast-feeding or to continue/discontinue therapy with Glypressin & Solvent for Acetate should be made taking into account the benefit of breast-feeding to the child and the benefit of Glypressin & Solvent for Acetate therapy to the woman.


Hypersensitivity to the active substance or to any of the excipients of Glypressin & Solvent for Acetate. Contraindicated in pregnancy.

Acute Overdose

The recommended dose in the specific patient population should not be exceeded as the risk of severe circulatory adverse effects is dose-dependent. Elevated blood pressure in patients with recognised hypertension can be controlled with 150 mcg clonidine i.v. Bradycardia requiring treatment should be treated with atropine.

Storage Condition

Store in a refrigerator (2-8°C). Keep the ampoules in the outer carton in order to protect from light.

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