Glutethimide
Glutethimide Uses, Dosage, Side Effects, Food Interaction and all others data.
Glutethimide is a hypnotic and sedative. Its use has been largely superseded by other drugs.
Glutethimide, like the barbiturates, is a hypnotic sedative. It was introduced in 1954 as a safer alternative to barbiturates but was soon determined to be just as likely to cause addiction and withdrawal symptoms.
| Trade Name | Glutethimide |
| Generic | Glutethimide |
| Glutethimide Other Names | Glutethimide, Glutetimida |
| Type | |
| Formula | C13H15NO2 |
| Weight | Average: 217.2637 Monoisotopic: 217.110278729 |
| Groups | Approved, Illicit |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
For the treatment of insomnia.
How Glutethimide works
Glutethimide seems to be a GABA agonist which helps induce sedation. It also induces CYP 2D6. When taken with codeine, it enables the body to convert higher amounts of codeine (higher than the average 5 - 10%) to morphine. This combination of effects enhances sedation.
Toxicity
In adults, death has been reported after 5 g. The usual lethal dose is 10 to 20g, although survival after a dose of 28 g has been reported.
Food Interaction
- Avoid alcohol.
- Take with or without food. The absorption is unaffected by food.
Elimination Route
Variable
Half Life
10-12 hours
Elimination Route
glutethimide is inactivated by conjugation and the metabolites are excreted in urine, only 2% of the parent substance is excreted in urine, up to 2% of the dose has been reported to be found in the faeces.
Innovators Monograph
You find simplified version here Glutethimide
