Gastroquinolone

Gastroquinolone Uses, Dosage, Side Effects, Food Interaction and all others data.

Gastroquinolone is a fluoroquinolone antibiotic indicated in the treatment of acute otitis externa (swimmer's ear) caused by the bacteria Pseudomonas aeruginosa and Staphylococcus aureus. Gastroquinolone is marketed by Novartis under the brand Xtoro™, and was approved by the FDA in December 2014.

Trade Name Gastroquinolone
Generic Finafloxacin
Finafloxacin Other Names Finafloxacin, gastrochinolon, gastroquinolone
Type
Formula C20H19FN4O4
Weight Average: 398.394
Monoisotopic: 398.139033271
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Gastroquinolone
Gastroquinolone

Uses

Gastroquinolone is indicated for the treatment of acute otitis externa (AOE) with or without an otowick, caused by susceptible strains of Pseudomonas aeruginosa and Staphylococcus aureus in patients age 1 year and older.

Gastroquinolone is also used to associated treatment for these conditions: Acute Otitis Externa

How Gastroquinolone works

Gastroquinolone is a fluoroquinolone antibiotic, which selectively inhibit bacterial type II topoisomerase enzymes, DNA gyrase and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair and recombination.

Toxicity

-Gastroquinolone was shown to be genotoxic and clastogenic in vitro, with and without metabolic activation, and in vivo. -General toxicity studies in rats have confirmed sperm toxicity following oral and intravenous dosing. -At 500 mg/kg/day, males were completely infertile, presumably due to low sperm count and sperm immobility.

Innovators Monograph

You find simplified version here Gastroquinolone

*** Taking medicines without doctor's advice can cause long-term problems.
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