Foscarmet

Foscarmet Uses, Dosage, Side Effects, Food Interaction and all others data.

An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarmet also shows activity against human herpes viruses and HIV.

Foscarmet is an organic analogue of inorganic pyrophosphate that inhibits replication of herpes viruses in vitro including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Foscarmet does not require activation (phosphorylation) by thymidine kinase or other kinases and therefore is active in vitro against HSV TK deficient mutants and CMV UL97 mutants. Thus, HSV strains resistant to acyclovir or CMV strains resistant to ganciclovir may be sensitive to foscarnet. However, acyclovir or ganciclovir resistant mutants with alterations in the viral DNA polymerase may be resistant to foscarnet and may not respond to therapy with foscarnet. The combination of foscarnet and ganciclovir has been shown to have enhanced activity in vitro.

Trade Name Foscarmet
Availability Prescription only
Generic Foscarnet
Foscarnet Other Names Carboxyphosphonic acid, Foscarmet, Phosphonoformate, Phosphonoformic acid, Phosphonomethanoic acid
Related Drugs acyclovir, valacyclovir, Valtrex, Zovirax, famciclovir, ganciclovir ophthalmic, valganciclovir, Valcyte, Famvir, cidofovir
Type
Formula CH3O5P
Weight Average: 126.0053
Monoisotopic: 125.971809718
Protein binding

14-17%

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Foscarmet
Foscarmet

Uses

Foscarmet is an antiviral used to treat CMV, HIV, and HSV infections.

For the treatment of CMV retinitis in patients with acquired immunodeficiency syndrome (AIDS) and for treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients.

Foscarmet is also used to associated treatment for these conditions: Chickenpox, Cytomegalovirus Retinitis, Genital Herpes, Herpes Labialis, Herpetic whitlow

How Foscarmet works

Foscarmet exerts its antiviral activity by a selective inhibition at the pyrophosphate binding site on virus-specific DNA polymerases at concentrations that do not affect cellular DNA polymerases.

Toxicity

Oral, rat LD50: >2,000 mg/kg. Signs of overdose include renal impairment.

Food Interaction

No interactions found.

Elimination Route

Poorly absorbed after oral administration (bioavailability from 12 to 22%).

Half Life

3.3-6.8 hours

Clearance

  • 2.13 +/- 0.71 mL/min/kg [patients had normal renal function (CrCl > 80 mL/min]
  • 68 +/- 8 mL/min/kg [CrCl was 50-80 mL/min]
  • 34 +/- 9 mL/min/kg [CrCl was 25-49 mL/min]
  • 20 +/- 4 mL/min/kg [CrCl was 10 - 24 mL/min]

Innovators Monograph

You find simplified version here Foscarmet

http://classyfire.wishartlab.com/tax_nodes/C0000000
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http://classyfire.wishartlab.com/tax_nodes/C0000364
http://classyfire.wishartlab.com/tax_nodes/C0004557
http://classyfire.wishartlab.com/tax_nodes/C0000400
http://classyfire.wishartlab.com/tax_nodes/C0000323
http://classyfire.wishartlab.com/tax_nodes/C0003940
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:127780
http://www.hmdb.ca/metabolites/HMDB0014670
http://www.genome.jp/dbget-bin/www_bget?drug:D00579
http://www.genome.jp/dbget-bin/www_bget?cpd:C06456
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3415
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46507873
https://www.chemspider.com/Chemical-Structure.3297.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50011181
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=33562
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=127780
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL666
https://zinc.docking.org/substances/ZINC000008101109
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP001383
http://www.pharmgkb.org/drug/PA449706
https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/PPF
http://www.rxlist.com/cgi/generic2/foscarnet.htm
https://www.drugs.com/cdi/foscarnet.html
https://en.wikipedia.org/wiki/Foscarnet
*** Taking medicines without doctor's advice can cause long-term problems.
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