Flona
Flona Uses, Dosage, Side Effects, Food Interaction and all others data.
Flona is a synthetic glucocorticoid. These drugs are available as inhalers, nasal, sprays, and topical treatments for various inflammatory indications. Flona was first approved in 1990.
Systemically, fluticasone propionate activates glucocorticoid receptors, and inhibits lung eosinophilia in rats. Flona as a topical formulation is also associated with vasoconstriction in the skin.
| Trade Name | Flona |
| Generic | Fluticasone propionate |
| Fluticasone propionate Other Names | Fluticasone propionate |
| Weight | 50mcg/spray |
| Type | Nasal Spray |
| Formula | C25H31F3O5S |
| Weight | Average: 500.571 Monoisotopic: 500.184429407 |
| Protein binding | Fluticasone propionate is 99% protein bound in serum. Topical fluticasone propionate is only 91% protein bound in serum however. |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | Square Pharmaceuticals Ltd |
| Available Country | Bangladesh |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Flona is a glucocorticoid used to treat asthma, inflammatory pruritic dermatoses, and nonallergic rhinitis.
Flona is indicated as an inhaler for the treatment and management of asthma by prophylaxisas well as inflammatory and pruritic dermatoses. Flona nasal spray is indicated for managing allergic and nonallergic rhinitis.
Flona is also used to associated treatment for these conditions: Allergic Rhinitis (AR), Allergy to Mold, Allergy; Dander, Asthma, Bacterial Sinusitis, Chronic Bronchitis, Chronic Obstructive Pulmonary Disease (COPD), Chronic Sinusitis, Dermatitis, Emphysema, House Dust Mite Allergy, House dust allergy, Itching of the nose, Nasal Congestion, Nonallergic Rhinitis, Oesophagitis, Eosinophilic, Perennial Rhinitis, Pollen Allergy, Rhinitis, Rhinorrhoea, Seasonal Allergic Rhinitis, Sneezing, Moderate, severe Perennial Allergic Rhinitis (PAR), Moderate, severe Seasonal Allergic Rhinitis
How Flona works
Flona works through an unknown mechanism to affect the action of various cell types and mediators of inflammation. Flona activates glucocorticoid receptors and inhibits lung eosinophilia in rats.
Toxicity
Flona's use in specific populations has not been well studied. Flona is not carcinogenic, mutagenic, or clastogenic, nor did it affect fertility in animal studies. Subcutaneous fluticasone propionate has been shown to produce teratogenic effects in rats though oral administration does not. Generally, there are no reported adverse effects with fluticasone in pregnancy. Flona in human milk may cause growth suppression, effects on endogenous corticosteroid production, or other effects. Pediatric patients treated with fluticasone propionate ointment experienced adrenal suppression. Geriatric patients treated with fluticasone propionate did not show any difference in safety or efficacy compared to other patient groups, though older patients may be more sensitive to adverse effects. There is no difference in the clearance of fluticasone propionate across genders or race. Patients with hepatic impairment should be closely monitored due to the elimination mechanism.
Food Interaction
No interactions found.Volume of Distribution
The volume of distribution of intravenous fluticasone propionate is 4.2L/kg. A study of 24 healthy Caucasian males showed a volume of distribution at steady state of 577L following intravenous administration.
Elimination Route
Intranasal bioavailability of fluticasone propionate is 10. Intranasal exposure results in the majority of the dose being swallowed. Topical absorption of fluticasone propionate is very low but can change depending on a number of factors including integrity of the skin and the presence of inflammation or disease. A study of 24 healthy Caucasian males showed an inhaled bioavailability of 9.0%.
Half Life
7.8 hours for intravenous fluticasone propionate. A study of 24 healthy Caucasian males shows a half life of 14.0 hours following intravenous administration and 10.8 hours following inhalation.
Clearance
1093mL/min for fluticasone propionate. A study of 24 healthy Caucasian males showed a clearance of 63.9L/h following intravenous administration.
Elimination Route
Flona is mainly eliminated in the feces with 10,5.
Innovators Monograph
You find simplified version here Flona
FAQ
What is Flona used for?
Flona is used to relieve symptoms of rhinitis such as sneezing and a runny, stuffy, or itchy nose and itchy, watery eyes caused by hay fever or other allergies.Flona is also used to relieve symptoms of nonallergic rhinitis such as sneezing and runny or stuffy nose which are not caused by allergies.
How safe is Flona?
Flona aqueous nasal spray is safe and effective for children with seasonal allergic rhinitis.
How does Flona work?
Flona works by reducing the inflammation of the airways, allowing air to pass in and out of the lungs more easily.
What are the common side effects of Flona?
The common side of Flona are include:
- headache.
- dryness, stinging, burning or irritation in the nose.
- nausea.
- vomiting.
- diarrhea.
- bloody mucus in nose.
- dizziness.
Is Flona safe during pregnancy?
This drug should be used during pregnancy only if the benefit outweighs the risk to the fetus.Flona are safe to use throughout pregnancy and the regular recommended dosage is still appropriate..
Is Flona safe during breastfeeding?
Nasal sprays containing beclomethasone,Flona may be used while breastfeeding. Topical eyedrops for allergies and hayfever may be used as the amount transferred into breastmilk is low.
Can I drink alcohol with Flona?
Yes, you can drink alcohol while taking Flona.
Is Flona a strong steroid?
Flona a potent corticosteroid with high specificity for the glucocorticoid receptor, is available as an aqueous nasal spray for the treatment of allergic rhinitis.
Does Flona weaken immune system?
Flona can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or recently had.
Is it safe to take Flona everyday?
You may start to feel relief after the first day—and full effect after several days of regular once-a-day use. Use Flona every day as full effectiveness is usually achieved after 3 or 4 days of continuous use.
When should I take Flona?
You should Flona is used to treat sneezing, itchy or runny nose, or other symptoms caused by hay fever.Even if you take it in the morning, you're still covered for all night long, without pesky allergy symptoms.
When should I not use Flona?
You should not be used to treat symptoms caused by the common cold.
Does Flona make me gain weight?
One alternative are nasal steroid sprays like Flona.These work differently from oral steroids, and are generally not associated with weight gain.
How long does it take for Flona to work?
You may feel an effect as soon as 12 hours after starting treatment, but it may take several days before you get the full benefit.If your condition does not improve after 1 week, or if it worsens, stop using this medication and consult your doctor or pharmacist.
Does Flona raise blood pressure?
When used as directed, Flona products do not increase blood pressure.
Can Flona make me anxious?
There is never a single issue that causes anxiety, and even with the relief you get from the medication your anxiety is likely to last. In fact, there is some evidence that Flona can actually cause anxiety as a side effect.
What happen if I forget a dose of Flona?
Use the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not use a double dose to make up for a missed one.
What happens if I overdose of Flona?
Overdose of Flona nasal is not expected to produce life threatening symptoms.Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems.
What happens when I stop using Flona?
If you suddenly stop taking the drug, you may also have withdrawal symptoms.
