Flaxedil

Flaxedil Uses, Dosage, Side Effects, Food Interaction and all others data.

Gallamine triethiodide is a benzylisoquinolinium competitive neuromuscular blocker. It is used to produce muscle relaxation in general anaesthesia during surgical procedures and to aid controlled ventilation.

Flaxedil is a nondepolarizing neuromuscular blocking drug (NDMRD) used as an adjunct to anesthesia to induce skeletal muscle relaxation. The actions of gallamine triethiodide are similar to those of tubocurarine, but this agent blocks the cardiac vagus and may cause sinus tachycardia and, occasionally, hypertension and increased cardiac output. Muscle groups differ in their sensitivity to these types of relaxants with ocular muscles (controlling eyelids) being most sensitive, followed by the muscles of the neck, jaw, limbs and then abdomen. The diaphragm is the least sensitive muscle to NDMRDs. Although the nondepolarizing neuromuscular blocking drugs do not have the same adverse effects as succinylcholine, their onset of action is slower. They also have a longer duration of action, making them more suitable for maintaining neuromuscular relaxation during major surgical procedures.

Trade Name Flaxedil
Generic Gallamine Triethiodide
Gallamine Triethiodide Other Names Gallamin triethiodid, Gallamine triethiodide, Gallamini Triethiodidum, TriƩthiodure de Gallamine, Trietioduro de galamina
Weight 120mg/3ml,
Type Injection
Formula C30H60I3N3O3
Weight Average: 891.5291
Monoisotopic: 891.176873061
Groups Approved
Therapeutic Class Non depolarizing muscle relaxants
Manufacturer Sanofi Bangladesh LTD,
Available Country Bangladesh,
Last Updated: September 19, 2023 at 7:00 am
Flaxedil
Flaxedil

Uses

Aid controlled ventilation, Anaesthesia, General anaesthesia, Muscle relaxant

How Flaxedil works

It competes with acetylcholine (ACh) molecules and binds to muscarinic acetylcholine receptors on the post-synaptic membrane of the motor endplate. It acts by combining with the cholinergic receptor sites in muscle and competitively blocking the transmitter action of acetylcholine. It blocks the action of ACh and prevents activation of the muscle contraction process. It can also act on nicotinic presynaptic acetylcholine receptors which inhibits the release of ACh.

Dosage

Flaxedil dosage

Aid controlled ventilation, Muscle relaxant in general anaesthesia:

  • Adult:Test dose: 20 mg may be given before anesth to determine drug sensitivity. Initially, 80-120 mg via IV inj, further doses of 20-40 mg may be given as required.
  • Child:1.5 mg/kg. Neonates: 600 mcg/kg.

Side Effects

Tachycardia, increased BP.

Precaution

Careful dose titration and monitoring of the degree of block are required to prevent overdosage.

Interaction

Lidocaine, procainamide, quinidine, and verapamil may enhance the block. Clindamycin can prolong the action of muscle relaxants. Apnoea may be prolonged when used with polymyxins. Anticholinesterases or long-term treatment with corticosteroids may antagonise the action of gallamine.

Pregnancy & Breastfeeding use

Pregnancy category- Not classified

Contraindication

Severe renal impairment. Hypersensitivity to iodine. Mysasthenia gravis.

Innovators Monograph

You find simplified version here Flaxedil

*** Taking medicines without doctor's advice can cause long-term problems.
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