Feiba Nf

Feiba Nf Uses, Dosage, Side Effects, Food Interaction and all others data.

Feiba Nf, also known as FEIBA (factor eight inhibitor bypassing activity), contains several proteins involved in the prothrombinase complex. It is used to control bleeding in hemophilia A and B patients with inhibitors.

FEIBA contains several clotting factors which act at various points in the caogulation cascade to promote thrombosis .

Table Of contents

• Feiba Nf
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Feiba Nf
Generic	Anti-inhibitor coagulant complex
Anti-inhibitor coagulant complex Other Names	Activated prothrombin complex concentrate, Antiinhibitor coagulant complex, Factor VIII bypassing fraction, Factor VIII inhibitor bypassing activity, Factor VIII inhibitor bypassing fraction
Weight	+,
Type	Intravenous Powder For Injection, Intravenous
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country	United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Feiba Nf is a medication used to control bleeding episodes and prevent bleeding episodes in hemophilia A and B.

For use in the control of bleeding episodes, perioperative management, and routine prophylaxis against bleeding episodes in hemophilia A and B patients with inhibitors . It is not indicated in the absence of factor VIII or IX inhibitors.

Feiba Nf is also used to associated treatment for these conditions: Bleeding caused by Hemophilia A, Bleeding caused by Hemophilia B, Perioperative bleeding caused by Hemophilia A, Perioperative bleeding caused by Hemophilia B

How Feiba Nf works

Factor VIIa present in FEIBA forms a complex with tissue factor and calcium which converts endogenous and FEIBA contained factor X to Xa . Endogenous and FEIBA contained factor Xa act as parrt of the prothrombinase complex to convert endogenous and FEIBA contained prothrombin to thrombin. Endogenous and FEIBA contained thrombin then cleave fibrinogen to insulouble fibrin and activate factor XIII which covalently cross-links fibrin to form a polymer mesh. FEIBA also contains factor IX and IXa which act as part of the tenase complex to convert factor X to Xa. Thrombin activates factor V, VII, and VIII as part of the amplification phase of the clotting cascade. These events promote the formation of blood clots to prevent or stop bleeding.

Toxicity

FEIBA is associated with increased risk of thromboembolic events such as stroke, myocardial infarction, and deep vein thrombosis .

Food Interaction

No interactions found.

Half Life

Plasma half lives of included clotting factors are as follows : Prothrombin - 65h Factor VII - 5h Factor IX - 25h Factor X - 40h

Innovators Monograph

You find simplified version here Feiba Nf